Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target

Fabio Barra, Lorenzo Ferro Desideri, Umberto Leone Roberti Maggiore, Leone Roberti Maggiore U, Valerio Gaetano Vellone, Gaetano Vellone V, Maramai M, Mattia Maramai, Scala C, Carolina Scala, Simone Ferrero, Ferrero S
International journal of fertility & sterility · 2020 · vol. 14(1) , pp. 76–77 · doi:10.22074/ijfs.2020.5876 · PMID:32112641 · PMC7139220 · W3011122234
Other OA: gold CC0 ⤵ 4 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This study investigated tumor necrosis factor-alpha (TNF-α) genetic polymorphisms in Iranian endometriosis patients, finding a non-significant trend for a lower frequency of the TNF-α -863C/A allele A in affected individuals compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

In the recent original research published on International Journal of Fertility and Sterility the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and endometriosis in 150 Iranian patients suffered this disease. The authors notably found a lower frequency of TNF-α -863C/A allele A among the affected patients in comparison with healthy women, although this difference was not significant by adjusting multiple testing. We deem that the authors should specify, if these patients had peritoneal nodules, ovarian endometrioma/deep infiltrating endometriosis (DIE) nodules or combination of them, since it has been hypothesized that these phenotypes may represent three distinct pathogenetic entities of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosisdie_deep_infiltratingendometrioma

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (16)

Cited by (3)

Source provenance

europepmc
last seen: 2026-10-18T09:30:06.152893+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:26:49.206298+00:00
License: CC0 · commercial use OK