Zooming in on the endometrial factor of recurrent implantation failure

Chibuzor Ifenatuoha, Ifenatuoha C, Babatunde Okewale, Okewale B
Human fertility (Cambridge, England) · 2021 · vol. 25(5) , pp. 848–859 · doi:10.1080/14647273.2021.1925976 · PMID:34002655 · W3162056714
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This review examines how endometrial pathologies like polyps, adenomyosis, and Asherman's syndrome negatively impact endometrial receptivity and embryo implantation, contributing to recurrent implantation failure.

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Abstract

Recurrent implantation failure (RIF) is a major limiting factor in the success rates of in-vitro fertilisation despite the remarkable clinical and technological advancement made at improving assisted reproductive technology. The primary purpose of the endometrium is to provide a receptive site for the implantation of the blastocyst and support its growth and subsequent development. Endometrial pathologies such as endometrial polyps, adenomyosis, Asherman's syndrome, chronic endometritis, and congenital Müllerian ducts defect negatively influence the integrity and receptivity of the endometrium, as well as the implantation of the embryo. This review highlights the implications of these endometrial pathologies and their association with RIF.

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Condition tags

adenomyosis

MeSH descriptors

Embryo Implantation Embryo Implantation Endometrium Endometrium Endometrium Blastocyst Blastocyst Embryo, Mammalian Embryo, Mammalian Female Female Fertilization in Vitro Fertilization in Vitro Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (97)

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License: CC0 · commercial use OK