Endometriosis: a new look at an old problem

О. L. Lovkina, I. V. Prolygina, I. V. Oleksiienko
In: Reports of Vinnytsia National Medical University · 2025 · vol. 29(2) , pp. 311–316 · doi:10.31393/reports-vnmedical-2025-29(2)-24 · W4411746863
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This systematic review identified pain as the most common symptom and ultrasound as the most frequently used diagnostic imaging method for endometriosis, with histological examination being the definitive diagnostic step.

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This paper examines diagnosis trends and features of endometriosis by ectopic lesion location using a systematic review and meta-analysis of 44 publications, drawing on descriptive and case-based literature identified from Scopus, PubMed, Web of Science, UpToDate, and other sources. Across 26 clinical cases (30 women, mean age 36.9 years), the most common complaint across locations was pain with an average symptom duration of 264.3 days, and ultrasound was the most frequently used examination method (50%), with lesion sizes averaging 3.2×2.0 cm in 11 studies; final diagnosis was most often based on postoperative histological examination, and the authors state that biomarkers have not yet enabled reliable blood-test diagnosis. A key limitation is the small number of described patients from clinical cases, which restricts generalizability. This paper is centrally about endometriosis — it synthesizes diagnosis patterns across ectopic locations and highlights diagnostic challenges such as reliance on imaging and histology.

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Abstract

Annotation. Endometriosis is a disease of women of adolescent and reproductive age, which is characterised by ectopic endometrial tissue and is usually associated with chronic pain and infertility. This disease affects 10-15% of women of reproductive age and 35-50% of women with pelvic pain and/or infertility. It should be noted that there are also cases of endometriosis in women in the postmenopausal period. The aim of the study was to identify the main trends and features of endometriosis diagnosis depending on its location. In the course of the study, a systematic review and meta-analysis of foreign and domestic literature was carried out using descriptive, bibliosemantic and statistical methods. The sources were scientific articles, namely systematic reviews and descriptions of clinical cases from the scientometric databases Scopus, PubMed, Web of Science, UpToDate and other publications. The total number of scientific sources is 44 articles. The literature search was carried out using the following Keywords: “endometriosis”, “women of reproductive age”, “gynecology”, “endometrial infiltration” and “ectopic localisation”. The total number of patients with endometriosis described in the 26 clinical cases studied is 30 women. The average age of the women was 36,9 years. Diagnosis endometriosis, as an interdisciplinary pathology, requires a comprehensive approach. First of all, it is a collection of complaints and medical history. It has been established that the most common complaint in endometriosis of any location is pain. The average determined duration of the symptom is 264,3 days, which indicates the prevalence of chronic forms of pathology. Despite research on biomarkers biomarkers, no blood test can reliably diagnose endometriosis, so priority is given to instrumental research methods. It was found that the most commonly used method of examination is ultrasound (15 cases (50%)). The average size of the lesions according to 11 studies was 3.2 cm by 2.0 cm. Additional imaging modalities included computed tomography (CT), magnetic resonance imaging (MRI), diagnostic laparoscopy and colonoscopy with biopsy. The most common method of final is a postoperative histological examination.
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Endometriosis: a new look at an old problem DOI: https://doi.org/10.31393/reports-vnmedical-2025-29(2)-24Keywords: endometriosis, ectopic location, reproductive age, endometrial infiltration, gynaecology.Abstract Annotation. Endometriosis is a disease of women of adolescent and reproductive age, which is characterised by ectopic endometrial tissue and is usually associated with chronic pain and infertility. This disease affects 10-15% of women of reproductive age and 35-50% of women with pelvic pain and/or infertility. It should be noted that there are also cases of endometriosis in women in the postmenopausal period. The aim of the study was to identify the main trends and features of endometriosis diagnosis depending on its location. In the course of the study, a systematic review and meta-analysis of foreign and domestic literature was carried out using descriptive, bibliosemantic and statistical methods. The sources were scientific articles, namely systematic reviews and descriptions of clinical cases from the scientometric databases Scopus, PubMed, Web of Science, UpToDate and other publications. The total number of scientific sources is 44 articles. The literature search was carried out using the following Keywords: “endometriosis”, “women of reproductive age”, “gynecology”, “endometrial infiltration” and “ectopic localisation”. The total number of patients with endometriosis described in the 26 clinical cases studied is 30 women. The average age of the women was 36,9 years. Diagnosis endometriosis, as an interdisciplinary pathology, requires a comprehensive approach. First of all, it is a collection of complaints and medical history. It has been established that the most common complaint in endometriosis of any location is pain. The average determined duration of the symptom is 264,3 days, which indicates the prevalence of chronic forms of pathology. Despite research on biomarkers biomarkers, no blood test can reliably diagnose endometriosis, so priority is given to instrumental research methods. It was found that the most commonly used method of examination is ultrasound (15 cases (50%)). The average size of the lesions according to 11 studies was 3.2 cm by 2.0 cm. Additional imaging modalities included computed tomography (CT), magnetic resonance imaging (MRI), diagnostic laparoscopy and colonoscopy with biopsy. The most common method of final is a postoperative histological examination. Downloads References Agarwal, S. K., Chapron, C., Giudice, L. C., Laufer, M. R., Leyland, N., Missmer, S. A., … & Taylor, H. S. (2019). Clinical diagnosis of endometriosis: a call to action. American journal of obstetrics and gynecology, 220(4), 354.e1-354.e12. https://doi.org/10.1016/j.ajog.2018.12.039 Allaire, C., Bedaiwy, M. A., & Yong, P. J. (2023). Diagnosis and management of endometriosis. CMAJ: Canadian Medical Association journal = Journal de l'Association medicale canadienne, 195(10), E363-E371. https://doi.org/10.1503/cmaj.220637 AlSinan, F. M., Alsakran, A. S., Foula, M. S., Al Omoush, T. M., & Al-Bisher, H. (2021). Inguinal Endometriosis in a Nulliparous Woman Mimicking an Inguinal Hernia: A Case Report with Literature Review. The American journal of case reports, (22), e934564. https://doi.org/10.12659/AJCR.934564 Alvarado, L. E. R., Bahmad, H., Mejia, O., Hollembeak, H., Poppiti, R., Howard, L., & Muddasani, K. (2021). Rectal endometriosis presenting as toxic megacolon. Autopsy & case reports, (11), e2021319. https://doi.org/10.4322/acr.2021.319 Becker, C. M., Bokor, A., Heikinheimo, O., Horne, A., Jansen, F., Kiesel, L & Vermeulen, N. (2022). ESHRE guideline: endometriosis. Human reproduction open, 2022(2), hoac009. https://doi.org/10.1093/hropen/hoac009 Borghese, B., Santulli, P., Marcellin, L., & Chapron, C. (2018). Définition, description, formes anatomo-cliniques, pathogenèse et histoire naturelle de l’endométriose, RPC Endométriose CNGOF-HAS [Definition, description, clinicopathological features, pathogenesis and natural history of endometriosis: CNGOF-HAS Endometriosis Guidelines]. Gynecologie, obstetrique, fertilite & senologie, 46(3), 156-167. https://doi.org/10.1016/j.gofs.2018.02.017 Boychuk, A., Herman, D., Dubosarska, Y., Zakharenko, N., Kalugina, L., Kosei, N., … & Yarotska, N. (2023). Resolution of the First Ukrainian Endometriosis Forum «Medical Treatment of Endometriosis-Associated Pelvic Pain. Quality of Life of a Woman». Репродуктивна ендокринологія – Reproductive Endocrinology, (70), 8-14. https://doi.org/10.18370/2309-4117.2023.70.8-14 Chen, M., Yu, Y., & Zhao, X. (2023). Endometriosis in an ectopic kidney: a rare case report and literature review. BMC women's health, 23(1), 203. https://doi.org/10.1186/s12905-023-02343-x De Graaff, A. A., D'Hooghe, T. M., Dunselman, G. A., Dirksen, C. D., & Hummelshoj, L. (2013). The significant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey. Human reproduction (Oxford, England), 28(10), 2677-2685. https://doi.org/10.1093/humrep/det284 Dhingra, H., Baliyan, A., Nagpal, R., & Pant, S. (2022). Intraluminal Endometriosis: A Rare Entity. Journal of mid-life health, 13(1), 88-90. https://doi.org/10.4103/jmh.jmh_149_21 Giannella, L., Serri, M., Maccaroni, E., DI Giuseppe, J., Carpini, G. D., Berardi, R., … & Ciavattini, A. (2020). Endometriosis-associated Clear Cell Carcinoma of the Abdominal Wall After Caesarean Section: A Case Report and Review of the Literature. In vivo (Athens, Greece), 34(4), 2147-2152. https://doi.org/10.21873/invivo.12021 Gonzalez, R. H., Singh, M. S., & Hamza, S. A. (2021). Cutaneous Endometriosis: A Case Report and Review of the Literature. The American journal of case reports, (22), e932493. https://doi.org/10.12659/AJCR.932493 Heijink, T., Bogers, H., & Steensma, A. (2020). Endometriosis of the Bartholin gland: a case report and review of the literature. Journal of medical case reports, 14(1), 85. https://doi.org/10.1186/s13256-020-02424-7 Jacquot, A., Gertych, W., Golfier, F., Devouassoux-Shisheboran, M., & Rousset, P. (2020). Polypoid endometriosis of the Douglas pouch. Radiology case reports, 16(3), 612-614. https://doi.org/10.1016/j.radcr.2020.12.054 Klein, S., Tourangeau-Young, R., & Biglione, A. (2023). Appendiceal Endometriosis Presenting As Chronic Appendicitis: A Case Report. Cureus, 15(4), e37825. https://doi.org/10.7759/cureus.37825 Leone Roberti Maggiore, U., Ferrero, S., Mangili, G., Bergamini, A., Inversetti, A., Giorgione, V., … & Candiani, M. (2016). A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Human reproduction update, 22(1), 70-103. https://doi.org/10.1093/humupd/dmv045 Lopez, M. P. J., Chan, V., Melendres, M. F., & Lutanco, R. (2021). Appendiceal intussusception from endometriosis. BMJ case reports, 14(6), e241592. https://doi.org/10.1136/bcr-2021-241592 Loudyi, Z., Benammi, S., Bakali, Y., Aguouzoul, H., Alaoui, M., Sebbah, F., … & Hrora, A. (2023). Primary umbilical endometriosis: Surgical case report. JRSM open, 14(7), 20542704231182057. https://doi.org/10.1177/20542704231182057 (Retraction published JRSM Open. 2024 Jun 6; 15(6): 20542704241260529. doi: 10.1177/20542704241260529) Madnani, R., & Sonara, S. (2023). Mesonephric Cyst Endometrioma: Surgical Management of an Atypical Site Endometriosis. CRSLS: MIS case reports from SLS, 10(3), e2023.00029. https://doi.org/10.4293/CRSLS.2023.00029 Makena, D., Obura, T., Mutiso, S., & Oindi, F. (2020). Umbilical endometriosis: a case series. Journal of medical case reports, 14(1), 142. https://doi.org/10.1186/s13256-020-02492-9 Mittelstadt, S., Stäbler, A., Kolb, M., Krämer, B., Horvat, H., Reisenauer, C., & Bachmann, C. (2022). Acute endometriosis-related sigmoid perforation in pregnancy- case report. BMC pregnancy and childbirth, 22(1), 647. https://doi.org/10.1186/s12884-022-04973-9 Moazzami, B., Chaichian, S., Samie, S., Zolbin MM., Jesmi F., Akhlaghdoust M., … & Safari, D. (2021). Does endometriosis increase susceptibility to COVID-19 infections? A case-control study in women of reproductive age. BMC Women's Health, (21), 119. https://doi.org/10.1186/s12905-021-01270-z Mollazadeh, S., Najmabadi, K. M., Mirghafourvand, M., & Roudsari R. L. (2023). Sexual Activity during Menstruation as A Risk Factor for Endometriosis: A Systematic Review and Meta-Analysis. Int J Fertil Steril., 17(1), 1-6. doi: 10.22074/IJFS.2022.541102.1207 Moradi, M., Niazi, A., Parker, M., Sneddon, A., Lopez, V., & Ellwood, D. (2022). Endometriosis-associated Symptoms and Diagnostic Delay: An Online Survey. Journal of Obstetrics, Gynecology and Cancer Research, 7(6), 479-488. doi: 10.30699/jogcr.7.6.479 Nagarajan, H. D. P., Selvanathan, K., Gopalakrishnan, V., Ramamoorthy, R. V., & Gopalakrishnan, J. (2023). Scar Endometriosis vs Hemangioma: A Diagnostic Conundrum. Cureus, 15(10), e47674. https://doi.org/10.7759/cureus.47674 Nawaz, M. M., Masood, Y., Usmani, A. S., Basheer, M. I., Sheikh, U. N., & Mir, K. (2022). Renal endometriosis: A benign disease with malignant presentation. Urology case reports,(43), 102110. https://doi.org/10.1016/j.eucr.2022.102110 Nnoaham, K. E., Hummelshoj, L., Webster, P., d'Hooghe, T., de Cicco Nardone, F., de Cicco Nardone, C., … & World Endometriosis Research Foundation Global Study of Women's Health consortium (2011). Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertility and sterility, 96(2), 366-373.e8. https://doi.org/10.1016/j.fertnstert.2011.05.090 Nouri, B., Arab, M., & Nasiri, M. (2023). Endometriosis: Clinical, Magnetic Resonance Imaging and Pathologic Findings. Journal of Obstetrics, Gynecology and Cancer Research, 8(5), 481-487. doi: 10.30699/jogcr.8.5.481 Paramythiotis, D., Karlafti, E., Tsomidis, I., Iraklis, G., Malliou, P., Karakatsanis, A., & Antonios, M. (2022). Abdominal wall endometriosis: a case report. The Pan African medical journal, (41), 193. https://doi.org/10.11604/pamj.2022.41.193.33536 Parasar, P., Ozcan, P., & Terry, K. L. (2017). Endometriosis: Epidemiology, Diagnosis and Clinical Management. Current obstetrics and gynecology reports, 6(1), 34-41. https://doi.org/10.1007/s13669-017-0187-1 Ragab, M. I., Altabba, A. M., Hilmi, S., Attia, K. E., & Elnogoomi, A. I. (2023). Endometriosis Causing Large Bowel Obstruction: A Case Report. Cureus, 15(4), e37025. https://doi.org/10.7759/cureus.37025 Sachdeva, G., Divyashree, P. S., & Shailaja, N. (2022). A non-classical presentation of scar endometriosis during pregnancy: Case report and review of literature. JBRA assisted reproduction, 26(3), 563-566. https://doi.org/10.5935/1518-0557.20210100 Sarbazi, F., Akbari, E., & Nouri, B. Pain Management in Endometriosis. Interv Pain Med Neuromod., 2(1), e128043. https://doi.org/10.5812/ipmn-128043 Simoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., … D'Hooghe, T. (2012). The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Human reproduction (Oxford, England), 27(5), 1292-1299. https://doi.org/10.1093/humrep/des073 Singh, S., Soliman, A. M., Rahal, Y., Robert, C., Defoy, I., Nisbet, P., & Leyland, N. (2020). Prevalence, Symptomatic Burden, and Diagnosis of Endometriosis in Canada: Cross-Sectional Survey of 30 000 Women. Journal of obstetrics and gynaecology Canada: JOGC = Journal d'obstetrique et gynecologie du Canada: JOGC, 42(7), 829-838. https://doi.org/10.1016/j.jogc.2019.10.038 Taibi, S., Guellil, A., Yassin, K., Jabi, R., & Bouziane, M. (2025). Ileal Endometriosis: A Rare Case. Cureus, 17(2), e78413. https://doi.org/10.7759/cureus.78413 Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014). Endometriosis: pathogenesis and treatment. Nature reviews. Endocrinology, 10(5), 261-275. https://doi.org/10.1038/nrendo.2013.255 Verzoviti, I., Kalliouris, D., Boptsi, A., Kiriakos, N., & Keramidaris, D. (2023). Endometriosis in the Cecum: A Rare Clinical Entity. Cureus, 15(3), e35782. https://doi.org/10.7759/cureus.35782 Wahl, K. J., Yong, P. J., Bridge-Cook, P., & Allaire, C. (2021). Endometriosis in Canada: It Is Time for Collaboration to Advance Patient-Oriented, Evidence-Based Policy, Care, and Research. Journal of obstetrics and gynaecology Canada: JOGC = Journal d'obstetrique et gynecologie du Canada: JOGC, 43(1), 88-90. https://doi.org/10.1016/j.jogc.2020.05.009 Wang, D., Yang, Q., Wang, H., & Liu, C. (2021). Malignant transformation of hepatic endometriosis: a case report and literature review. BMC women's health, 21(1), 249. https://doi.org/10.1186/s12905-021-01366-6 Xu, R., Xia, X., Liu, Y., Du, X., Hao, Z., Wang, L., & Du, J. (2022). A case report of an endometriosis cyst at cesarean scar defect and review of literature. BMC pregnancy and childbirth, 22(1), 954. https://doi.org/10.1186/s12884-022-05311-9 Xu, Y., Xu, Y., Miao, L., Cao, M., Xu, W., & Shi, L. (2022). Comprehensive surgical treatment for obstructive rectal endometriosis: a case report and review of the literature. BMC women's health, 22(1), 280. https://doi.org/10.1186/s12905-022-01858-z Zihni, İ., Karaköse, O., Özçelik, K. Ç., Pülat, H., Eroğlu, H. E., & Bozkurt, K. K. (2020). Endometriosis within the inguinal hernia sac. Turkish journal of surgery, 36(1), 113-116. https://doi.org/10.5578/turkjsurg.3247 Zondervan, K. T., Becker, C. M., & Missmer, S. A. (2020). Endometriosis. The New England journal of medicine, 382(13), 1244-1256. https://doi.org/10.1056/NEJMra1810764

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