Additional file 1 of Gut microbiome in endometriosis: a cohort study on 1000 individuals

Inmaculada Pérez‐Prieto, Vargas, Eva, Salas-Espejo, Eduardo, Lüll, Kreete, Canha-Gouveia, Analuce, Pérez, Laura Antequera, Fontes, Juan, Salumets, Andres, Andreson, Reidar, Aasmets, Oliver, Whiteson, Katrine, Org, Elin, Altmäe, Signe
2024 · doi:10.6084/m9.figshare.26750456 · W6958876367
Observational OA: green CC0
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study analyzed gut microbiome data from 1000 individuals, identifying two enterotypes and finding no significant differences in microbial diversity or estrogen-related enzymes between endometriosis and control groups.

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Abstract

Additional file 1: Figures S1-S4. FigS1- Enterotypes model fit by the number of clusters. 2 clusters were selected as an optimal number based on the highest Silhouette Index. FigS2- Heatmap illustrating the top 20 most abundant species of the Estonian study population. The taxa are rank-ordered with the most abundant taxon on the left in the x-axis. Participants are displayed in the y-axis. FigS3- Sensitivity analysis of microbial diversity measures in endometriosis and control groups. (A, B) Alpha-diversity analysis (i.e., Shannon diversity index and observed richness) after excluding women with age > 50. Groups comparisons indicate no significant differences (Linear-mixed effects, all p-values > 0.05). (C, D) Beta-diversity analyses on the principal coordinates analysis (PCoA) of the species (C) and KOs (D) profile based on the Bray–Curtis dissimilarity (Adonis PERMANOVA, both R2 > 0.001, both p-values > 0.05). FigS4- Estrobolome analysis comparing endometriosis and control groups. Total read count from estrogen-related enzymes was not significantly different between groups (Mann Whitney U test: p-value > 0.05).

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (56)

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