BACKGROUND: Emerging evidence suggests microbial dysbiosis may contribute to gynaecological pathologies, including endometriosis and recurrent implantation failure (RIF). The vaginal microbiome is well-characterised, with Lactobacillus-domi…
Study questionDoes the analysis of endometrial microbes provide the same information when using DNA or RNA sequencing-based techniques?Summary answerDNA vs RNA-based microbial analysis techniques demonstrated significant microbial compositi…
Abstract Study question Does the microbial composition along the female reproductive tract (vagina, cervix and uterus) differ between women with and without endometriosis? Summary answer Slight differences in the microbial composition along…
BackgroundA didelphic uterus represents a unique and infrequent congenital condition in which a woman possesses two distinct uteri, each with its own cervix. This anomaly arises due to partial or incomplete merging of the Müllerian ducts du…
Additional file 1: Figures S1-S4. FigS1- Enterotypes model fit by the number of clusters. 2 clusters were selected as an optimal number based on the highest Silhouette Index. FigS2- Heatmap illustrating the top 20 most abundant species of t…
Additional file 1: Figures S1-S4. FigS1- Enterotypes model fit by the number of clusters. 2 clusters were selected as an optimal number based on the highest Silhouette Index. FigS2- Heatmap illustrating the top 20 most abundant species of t…
Additional file 2: Tables S1-S7. Table S1- Correlation analysis between gut enterotypes and clinical factors. Table S2- Differential abundance analysis in endometriosis and control groups. Species with a prevalence > 10% and relative abunda…
Additional file 2: Tables S1-S7. Table S1- Correlation analysis between gut enterotypes and clinical factors. Table S2- Differential abundance analysis in endometriosis and control groups. Species with a prevalence > 10% and relative abunda…
PURPOSE OF REVIEW: The analysis of microbiome in association with female health is today a "hot topic" with the main focus on microbes in the female reproductive tract. Nevertheless, recent studies are providing novel information of the pos…
Abstract Background Endometriosis, defined as the presence of endometrial-like tissue outside of the uterus, is one of the most prevalent gynecological disorders. Although different theories have been proposed, its pathogenesis is not clea…
Abstract Background Endometriosis, defined as the presence of endometrial-like tissue outside of the uterus, is one of the most prevalent gynecological disorders. Although different theories have been proposed, its pathogenesis is not clear…
BACKGROUND: Endometriosis, defined as the presence of endometrial-like tissue outside of the uterus, is one of the most prevalent gynecological disorders. Although different theories have been proposed, its pathogenesis is not clear. Novel …
Abstract Background Endometriosis, defined as the presence of endometrial-like tissue outside of the uterus, is one of the most prevalent gynecological disorders. Although different theories have been proposed, its pathogenesis is not clear…
Abstract Study question Does the endometrium possess alive, culturable bacteria, and are there any microbes associated with endometriosis? Summary answer Thirty-five cultured bacterial species were identified in the receptive-phase endometr…
Abstract Study question Do gut microbial composition and functionality differ between women with and without endometriosis? Summary answer Gut microbiome diversity and composition (species and microbial pathways) were not significantly diff…
IntroductionThe female reproductive tract harbours unique microbial communities (known as microbiota) which have been associated with reproductive functions in health and disease. While endometrial microbiome studies have shown that the ute…