Additional file 1 of Gut microbiome in endometriosis: a cohort study on 1000 individuals

Inmaculada Pérez‐Prieto, Vargas, Eva, Salas-Espejo, Eduardo, Lüll, Kreete, Canha-Gouveia, Analuce, Pérez, Laura Antequera, Fontes, Juan, Salumets, Andres, Andreson, Reidar, Aasmets, Oliver, Whiteson, Katrine, Org, Elin, Altmäe, Signe
2024 · doi:10.6084/m9.figshare.26750456.v1 · W6958930823
article OA: green CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study analyzed the gut microbiome in 1000 individuals, finding no significant differences in alpha-diversity, beta-diversity, or estrobolome between endometriosis and control groups.

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Abstract

Additional file 1: Figures S1-S4. FigS1- Enterotypes model fit by the number of clusters. 2 clusters were selected as an optimal number based on the highest Silhouette Index. FigS2- Heatmap illustrating the top 20 most abundant species of the Estonian study population. The taxa are rank-ordered with the most abundant taxon on the left in the x-axis. Participants are displayed in the y-axis. FigS3- Sensitivity analysis of microbial diversity measures in endometriosis and control groups. (A, B) Alpha-diversity analysis (i.e., Shannon diversity index and observed richness) after excluding women with age > 50. Groups comparisons indicate no significant differences (Linear-mixed effects, all p-values > 0.05). (C, D) Beta-diversity analyses on the principal coordinates analysis (PCoA) of the species (C) and KOs (D) profile based on the Bray–Curtis dissimilarity (Adonis PERMANOVA, both R2 > 0.001, both p-values > 0.05). FigS4- Estrobolome analysis comparing endometriosis and control groups. Total read count from estrogen-related enzymes was not significantly different between groups (Mann Whitney U test: p-value > 0.05).

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (56)

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