Hormonal postcoital contraception with an ethinylestradiol-norgestrel combination and two danazol regimens

G. Zuliani, U Colombo, U F Colombo, R Molla
European Journal of Obstetrics & Gynecology and Reproductive Biology · 1990 · vol. 37(3) , pp. 253–260 · doi:10.1016/0028-2243(90)90032-v · PMID:2227068 · W2091697381
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This study investigated the efficacy of hormonal postcoital contraception using ethinylestradiol-norgestrel and two danazol regimens.

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Abstract

The ethinylestradiol-norgestrel combination (EE-NG) for postcoital contraception, as described by Yuzpe, has been shown to be an effective method but with frequent side effects. To overcome the problem of adverse effects a new approach using danazol was proposed, but the efficacy and acceptability of this treatment have not yet been tested in large studies. In a 5-year period at the AIECS Family Planning Centre in Milan we treated 2448 women requesting postcoital contraception using Yuzpe's regimen and two danazol regimens (800 mg/1200 mg). The patients' acceptability for danazol treatment was higher than for Yuzpe's regimen due to fewer, milder and shorter side effects. Nine pregnancies occurred in the EE-NG group (2.21%), 17 in the 800 mg group (1.71%) and 6 in the 1200 mg group (0.82%). Our study shows a statistically significant efficacy against expected pregnancy rates both with Yuzpe's regimen and with danazol. The 1200 mg danazol treatment seems to be more effective and can be considered a valid alternative to the EE-NG combination for hormonal postcoital contraception.

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MeSH descriptors

Contraceptives, Postcoital, Hormonal Contraceptives, Postcoital, Hormonal Danazol Ethinyl Estradiol Norgestrel Adolescent Adult Danazol Drug Administration Schedule Drug Combinations Ethinyl Estradiol Female Humans Norgestrel Pregnancy

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