Uterine peristalsis in women with repeated IVF failures: possible therapeutic effect of hyoscine bromide

Aki Kido, Kaori Togashi, Hiroshi Hatayama, Takahiro Nakayama, Akira Yamamoto, Masako Kataoka, Togas Tulandi
Journal of Obstetrics and Gynaecology Canada · 2009 · vol. 31(8) , pp. 732–735 · doi:10.1016/s1701-2163(16)34278-5 · PMID:19772706 · W2187256994
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This study investigated uterine peristalsis in women with repeated IVF failures and explored the potential therapeutic benefits of hyoscine bromide.

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Abstract

BACKGROUND: Uterine peristalsis, which is influenced by hormonal and cholinergic effects, may have a role in successful implantation and continuing pregnancy. CASES: We encountered abnormal uterine peristalsis in three women who had had repeated in vitro fertilization (IVF) treatment failures. They subsequently had successful pregnancies when hyoscine bromide was administered at the time of embryo transfer. CONCLUSION: It is possible that decreasing uterine peristalsis with use of an anticholinergic agent during IVF treatment facilitates retention of embryos and increases the probability of successful pregnancy.

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MeSH descriptors

Cholinergic Antagonists Fertilization in Vitro Peristalsis Scopolamine Uterine Contraction Adult Cholinergic Antagonists Embryo Transfer Female Humans Peristalsis Pregnancy Scopolamine Treatment Failure Uterine Contraction

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