Uterine Peristalsis in Women With Repeated IVF Failures: Possible Therapeutic Effect of Hyoscine Bromide

Aki Kido, Kaori Togashi, Hiroshi Hatayama, Takahiro Nakayama, Akira Yamamoto, Masako Kataoka, Togas Tulandi
In: Journal of Obstetrics and Gynaecology Canada · 2009 · vol. 31(8) , pp. 732–735 · doi:10.1016/s1701-2163(16)34278-5 · PMID:19772706 · W2187256994
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This study investigated uterine peristalsis in women with repeated IVF failures and explored the potential therapeutic benefits of hyoscine bromide.

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Abstract

BackgroundUterine peristalsis, which is influenced by hormonal and cholinergic effects, may have a role in successful implantation and continuing pregnancy.CasesWe encountered abnormal uterine peristalsis in three women who had had repeated in vitro fertilization (IVF) treatment failures. They subsequently had successful pregnancies when hyoscine bromide was administered at the time of embryo transfer.ConclusionIt is possible that decreasing uterine peristalsis with use of an anticholinergic agent during IVF treatment facilitates retention of embryos and increases the probability of successful pregnancy.

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