ROLE OF EXTRAPOLATIVE FACTORS AND CIRCULATING BIOCHEMICAL INTERPLAY IN FEMALES WITH ENDOMETRIOSIS

Gholamreza Amin, Alvi Ht, Arif Malik, C Meuleman, D 'hoore, A Van Cleynenbreugel, B Beks, N, D' Hooghe, T, C Bulletti, M Coccia, S Battistoni, A Borini, P Carmeliet, R Jain, J Mclaren, T Hirano, K. Yamaguchi, M Mandai, S Toyokuni, J Hamanishi, T Higuchi, K Takakura, S Fujii, J Kao, B Rosenstein, S Peters, M Milano, S Kron, P Montuschi, P Barnes, L Roberts, G Sajal, A Agarwal, N Krajcir, J Alvarez, K Chad, W Darryn, B Luciana, C Fiore, G Dona, A Andrisani, G Ambrosini, D Faggian, M Plebani, Clari, G Chrousos, I Elenkov, A Lima, M Moura, Rosa Silva, Aam, A Delbandi, M Mahmoudi, A Shervin, A Zarnani, E Simpson, L Tea, T Nadeem, M Khan, B Ijaz, N Ahmed, Z Urrahman, M Latif, Q Ali, M Rana
In: International Journal of Biology, Pharmacy and Allied Sciences · 2018 · vol. 7(9) · doi:10.31032/ijbpas/2018/7.9.4548 · W4239411286
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This study investigated and identified altered levels of cytokines, matrix metalloproteinases, oxidative stress markers, and vitamin D in women with endometriosis compared to healthy controls.

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Abstract

Endometriosis is the primary cause of female infertility during reproductive age. It is due to the existence of endometrial glands and stromal tissues outside the wall of uterus. The particular prevalence of the disease is still unclear but approx. 5-10% of women are affected by endometriosis. The aim of this study is to pin point the role of cytokine, matrix metalloproteinases (MMPs) and steroid hormones in progression and aggregation of endometriosis. Hundred patients of endometriosis and hundred healthy age and sex matched individuals were recruited for the current study. The levels of MDA, IsoP-F2, 8-OHdG, SOD, GSH, CAT, IL-1, IL-2, IL-6, IL-10, IL-11, IL-13, IL-4, TNF-, MMP-1, MMP-2, MMP-8, MMP-9, MMP-13, cortisol, estradiol and vitamin D were estimated. It shows that levels of MDA were increased significantly in patients (1.990.045 nmol/ml) compared to control (0.98.0015 nmol/ml). The levels ofIsoP-F2 and 8-OHdG were recorded 34.264.26 pg/ml and 1.0220.0015 pg/ml respectively in patients. However, the serum CAT, SOD, GSH and vit D levels in patients were recorded with the significant decline values 3.160.015 IU/L, 0.0140.005 U/L, 6.591.6 mol/L and 14.264.66 pmol/L respectively. Serum MMP-8 and MMP-13 were increased in the patients of endometriosis (67.268.26 ng/ml and 98.264.26 ng/ml respectively). The levels of cytokines IL-4 (5.781.28 pg/ml),

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endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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