Effect of undiagnosed deep adenomyosis after failed NovaSure endometrial ablation

Bianca B. Mengerink, Mengerink BB, A.A.M. van der Wurff, Anneke A M van der Wurff, van der Wurff AA, Johanne F. ter Haar, ter Haar JF, van Rooij IA, Ilse A. van Rooij, Johanna M A Pijnenborg
Journal of Minimally Invasive Gynecology · 2014 · vol. 22(2) , pp. 239–244 · doi:10.1016/j.jmig.2014.10.006 · PMID:25460320 · W2037924696
Observational OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-22 ⓘ

This study investigated the occurrence of undiagnosed deep adenomyosis in patients experiencing persistent symptoms after undergoing NovaSure endometrial ablation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

STUDY OBJECTIVE: To determine the prevalence of adenomyosis and deep adenomyosis after NovaSure (Hologic Inc., Newark, DE) endometrial ablation in hysterectomy specimens after NovaSure endometrial ablation failure. DESIGN: Prospective observational study (Canadian Task Force classification II-2). SETTING: The TweeSteden Hospital, a teaching hospital in the south of the Netherlands. PATIENTS: All women who underwent hysterectomy for menorrhagia and/or dysmenorrhea after failure of NovaSure endometrial ablation between November 2007 and January 2011. INTERVENTIONS: All patients who underwent hysterectomy between January 2005 and April 2009 for the same indication but did not undergo prior endometrial ablation from choice or the lack of availability of the endometrial ablation procedure. MEASUREMENTS AND MAIN RESULTS: Of 213 patients who underwent NovaSure therapy, 22 (10.3%) underwent a hysterectomy because NovaSure failed. Of these, 10 (45.5%) exhibited adenomyosis in their hysterectomy specimens. The control group patients had a similar adenomyosis prevalence (74/173, 42.8%). However, the NovaSure failure group had a significantly higher prevalence of deep adenomyosis (>2.5 mm endometrial penetration) (9/22, 40.9%) than the control group (37/173, 21.4%, p < .05). CONCLUSION: Deep adenomyosis after failed NovaSure endometrial ablation was present in a significant number of patients. It is not clear whether adenomyosis is induced by endometrial ablation or whether it causes endometrial ablation failure.

My notes (saved in your browser only)

Condition tags

dysmenorrheaadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Dysmenorrhea Endometrial Ablation Techniques Hysterectomy Menorrhagia Adult Adult Dysmenorrhea Dysmenorrhea Endometrial Ablation Techniques Endometrial Ablation Techniques Endometrial Ablation Techniques Female Female Humans Humans Hysterectomy Hysterectomy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (13)

Source provenance

europepmc
last seen: 2026-10-14T06:08:39.101224+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:14:41.184593+00:00
unpaywall
last seen: 2026-10-14T06:23:58.021457+00:00
License: CC0 · commercial use OK