Effect of Undiagnosed Deep Adenomyosis After Failed NovaSure Endometrial Ablation

Bianca B. Mengerink, Mengerink BB, A.A.M. van der Wurff, Anneke A M van der Wurff, van der Wurff AA, Johanne F. ter Haar, ter Haar JF, van Rooij IA, Ilse A. van Rooij, Johanna M A Pijnenborg
Journal of Minimally Invasive Gynecology · 2014 · vol. 22(2) , pp. 239–244 · doi:10.1016/j.jmig.2014.10.006 · PMID:25460320 · W2037924696
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This study investigated the occurrence of undiagnosed deep adenomyosis in patients experiencing persistent symptoms after undergoing NovaSure endometrial ablation.

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Abstract

Study objectiveTo determine the prevalence of adenomyosis and deep adenomyosis after NovaSure (Hologic Inc., Newark, DE) endometrial ablation in hysterectomy specimens after NovaSure endometrial ablation failure.DesignProspective observational study (Canadian Task Force classification II-2).SettingThe TweeSteden Hospital, a teaching hospital in the south of the Netherlands.PatientsAll women who underwent hysterectomy for menorrhagia and/or dysmenorrhea after failure of NovaSure endometrial ablation between November 2007 and January 2011.InterventionsAll patients who underwent hysterectomy between January 2005 and April 2009 for the same indication but did not undergo prior endometrial ablation from choice or the lack of availability of the endometrial ablation procedure.Measurements and main resultsOf 213 patients who underwent NovaSure therapy, 22 (10.3%) underwent a hysterectomy because NovaSure failed. Of these, 10 (45.5%) exhibited adenomyosis in their hysterectomy specimens. The control group patients had a similar adenomyosis prevalence (74/173, 42.8%). However, the NovaSure failure group had a significantly higher prevalence of deep adenomyosis (>2.5 mm endometrial penetration) (9/22, 40.9%) than the control group (37/173, 21.4%, p < .05).ConclusionDeep adenomyosis after failed NovaSure endometrial ablation was present in a significant number of patients. It is not clear whether adenomyosis is induced by endometrial ablation or whether it causes endometrial ablation failure.

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Condition tags

dysmenorrheaadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Dysmenorrhea Endometrial Ablation Techniques Hysterectomy Menorrhagia Adult Dysmenorrhea Endometrial Ablation Techniques Endometrial Ablation Techniques Female Humans Hysterectomy Menorrhagia Middle Aged Netherlands Netherlands Prospective Studies Treatment Failure

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