Pregnancy outcomes after fresh versus vitrified-warmed embryo transfer in women with adenomyosis: a retrospective cohort study

Xingwang Zhu, Xing-Wang Zhu, Zhu X, Dongye H, Houjin Dongye, Lu S, Shaoming Lu, Xingbo Zhao, Zhao X, Xingbo Ζhao, Lei Yan, Yan L
Reproductive BioMedicine Online · 2022 · vol. 44(6) , pp. 1023–1029 · doi:10.1016/j.rbmo.2022.02.013 · PMID:35367131 · W4213456480
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This study compared pregnancy outcomes between fresh and vitrified-warmed embryo transfers in women diagnosed with adenomyosis.

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Abstract

RESEARCH QUESTION: Is the singleton live birth rate superior for vitrified-warmed versus fresh embryo transfer in women with adenomyosis? DESIGN: This cohort study retrospectively analysed data from the Reproductive Hospital Affiliated to Shandong University between January 2013 and December 2018. A total of 612 women diagnosed with adenomyosis, with 322 fresh embryo transfer cycles and 290 vitrified-warmed embryo transfer cycles, were included in this study. The primary outcome was singleton live birth. Outcomes were adjusted using multivariable logistic regression analysis. RESULTS: Vitrified-warmed embryo transfer was associated with a higher rate of singleton live birth than fresh embryo transfer (25.9% versus 17.4%; P = 0.011). Although there was a trend towards a lower miscarriage rate after vitrified-warmed embryo transfer, the difference did not reach statistical significance (31.3% versus 40.6%; P = 0.111). The clinical pregnancy rate was comparable in the two groups (44.1% versus 44.4%; P = 0.946). Vitrified-warmed embryo transfer also resulted in a lower risk of preterm birth than fresh embryo transfer (7.0% versus 17.5%; P = 0.010). CONCLUSIONS: Vitrified-warmed embryo transfer may be associated with better pregnancy outcomes than fresh embryo transfer among women with adenomyosis. It seems that vitrified-warmed embryo transfer is more appropriate for specific populations.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Premature Birth Premature Birth Premature Birth Premature Birth Premature Birth Premature Birth Cohort Studies Cohort Studies Cohort Studies Cohort Studies Cohort Studies Cryopreservation Cryopreservation Cryopreservation

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