Lu S

Objective: To investigate the burden of endometriosis (EMs)-related and polycystic ovary syndrome (PCOS)-related infertility among women aged 15-49 years in China and globally, and to project trends over the next 15 years. Methods: Data wer…

BACKGROUND: Dysmenorrhea impacts 45% to 95% of women of childbearing age globally. Research on the neuro-immune-endocrine regulatory network has grown by 22.3% annually over the past decade, yet the field faces challenges including fragment…

Endometriosis is a chronic estrogen-dependent disorder affecting up to 10% of women of reproductive age, and the absence of reliable noninvasive diagnostic tools contributes to delayed diagnosis and disease progression. To identify potentia…

BACKGROUND: Chronic pain resulting from postoperative adhesions represents a significant clinical concern due to its substantial impact on patient quality of life; however, optimal therapeutic management remains contentious. This systematic…

BACKGROUND: Evidence regarding maternal body mass index (BMI) and intrauterine insemination (IUI) outcomes remains controversial. This study aimed to evaluate such independent associations, focusing on potential non-linear patterns, clinica…

BACKGROUND: The clinical impact of sperm chromatin condensation defects (SCCD) on in vitro fertilization (IVF) outcomes remains controversial. This study aimed to clarify the effects of SCCD on embryonic development, pregnancy, and neonatal…

BACKGROUND AND AIMS: Menstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, an…

BACKGROUND: Undifferentiated endometrial carcinoma is a solid tumor that originates from endometrial epithelial cells, accounting for approximately 9% of endometrial cancers. Undifferentiated endometrial carcinoma exhibits high invasiveness…

BACKGROUND: Endometriosis is a chronic inflammatory disorder affecting ~ 10% of reproductive-age women, often causing pelvic pain and infertility. Despite its prevalence, diagnosis remains delayed due to non-specific symptoms and lack of re…

Acute pancreatitis (AP) is a common gastrointestinal emergency requiring hospitalization. In recent years, several studies have demonstrated a role for 4-octyl itaconate (4-OI) in anti-inflammatory and oxidative stress injury. However, the …

OBJECTIVE: Accurately predicting metastatic cancer to the adnexa, stage I and advanced ovarian cancer before surgery is crucial. The ADNEX model, based on ultrasound, is currently the only prediction model that can differentiate between the…

PURPOSE: This study aims to establish a single-time point RNA-sequencing-based endometrial receptivity test (rsERT) to provide hourly precision of endometrial WOI for patients with recurrent implantation failure (RIF). METHODS: A two-phase…

PURPOSE: Endometriosis (EM) and recurrent spontaneous abortion (RSA) exhibit clinical associations, yet their shared molecular mechanisms remain unclear. This study aimed to identify shared molecular mechanisms and potential hub genes under…

BACKGROUND: Cold exposure can induce microvascular damage, which in turn contributes to various gynecological disorders. Liangfang Wenjing Decoction (LFWJD), a classical botanical drug prescription, has long been used to treat gynecological…

STUDY QUESTION: Can third-generation sequencing (TGS)-based polar body (PB) analysis serve as a viable alternative to conventional trophectoderm (TE) biopsy for preimplantation genetic testing for aneuploidy (PGT-A)? SUMMARY ANSWER: This s…

The most common medications for the treatment of zoonotic toxoplasmosis are pyrimethamine and sulfadiazine, which may cause serious undesirable side effects. Thus, there is an urgent need to develop novel therapeutics. Baicalein (BAI, C15H1…

Abstract Endometriosis is a common yet often underdiagnosed condition, partly due to the lack of reliable diagnostics. This study examines the clinical feasibility of a blood-based, miRNA-driven test to diagnose endometriosis and address th…

Abstract Background Endometriosis is a chronic inflammatory disorder affecting ~ 10% of reproductive-age women, often causing pelvic pain and infertility. Despite its prevalence, diagnosis remains delayed due to non-specific symptoms and l…

BACKGROUND: Endometriosis is a common chronic gynecological condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to chronic inflammation, pelvic nodules and masses, pelvic pain, and infertility. …

PURPOSE: This study aimed to investigate the impact of paternal age > 40 years on clinical pregnancy and perinatal outcomes among patients undergoing in vitro fertilization treatment. METHODS: We selected 75 male patients (aged > 40 years)…

BACKGROUND: Non-invasive chromosome screening (NICS) and trophectoderm biopsy preimplantation genetic testing for aneuploidy (TE-PGT) were both applied for embryo ploidy detection, However, the cumulative live birth rates (CLBR) of NICS and…

ETHNOPHARMACOLOGICAL RELEVANCE: Endometriosis (EMs) is characterized by inflammatory lesions, dysmenorrhea, infertility, and chronic pelvic pain. Single-target medications often fail to provide systemic therapeutic results owing to the comp…

OBJECTIVE: Endometriosis (EMS) is an estrogen-dependent condition with unclear pathogenesis. Recent findings suggest implicate autophagy and ferroptosis in EMS development. METHODS: We assessed autophagy and ferroptosis proteins in EMS pat…

BACKGROUND: Embryo implantation in a receptive endometrium is crucial for successful pregnancy. Endometrial receptivity (ER) prediction tools based on endometrial transcriptome biomarkers by endometrial biopsy have been used to guide succes…

The litter trait is one of the most important economic traits, and increasing litter size is of great economic value in the pig industry. However, the molecular mechanisms underlying pig litter traits remain elusive. To identify molecular m…