Expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis is associated with endometriosis severity

Yongjie Tian, Ye Tian, Tian Y, Beihua Kong, B Kong, Kong B, W Zhu, Wengen Zhu, Zhu W, Shan Su, S. Su, Su S, Kan Y, Yuen‐Yee Kan, Y. Kan
The Journal of international medical research · 2009 · vol. 37(5) , pp. 1389–1395 · doi:10.1177/147323000903700513 · PMID:19930843 · W2091376942
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This study found that steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) are upregulated in ectopic endometriotic tissues and associated with endometriosis severity.

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Abstract

This study was designed to investigate the levels of expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis, and to explore the association between these two factors and the menstrual cycle and the severity of endometriosis. Levels of SF-1 and StAR protein were evaluated using immunohistochemistry in 38 cases of endometriosis with ectopic endometria and in 25 normal endometria (controls). The SF-1 and StAR protein levels were significantly higher in ectopic endometria than in normal endometria. There was a significant correlation between the level of SF-1 and StAR in ectopic endometriotic tissues. It is concluded that protein levels of SF-1 and StAR are upregulated in ectopic endometria and are significantly correlated with the severity of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Ovarian Neoplasms Peritoneal Neoplasms Phosphoproteins Steroidogenic Factor 1 Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (21)

Cited by (14)

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