Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via alpha5beta1 integrin

Hironori Matsumoto, Keiji Sakai, Kiyofumi Sakai, Mitsutoshi Iwashita, M. Iwashita
Molecular human reproduction · 2008 · vol. 14(8) , pp. 485–489 · doi:10.1093/molehr/gan038 · PMID:18583428 · W2137657922
Lab / animal OA: bronze CC0 ⤵ 7 in-corpus citations
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Insulin-like growth factor binding protein-1 (IGFBP-1) induced decidualization of human endometrial stromal cells via alpha5beta1 integrin, independent of progesterone stimulation.

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Abstract

Progesterone is known to induce decidualization of human endometrial stromal cells in vitro. Decidualized stromal cells produce insulin-like growth factor binding protein-1 (IGFBP-1) as well as prolactin (PRL). In this study, we tested the possibility that IGFBP-1 directly stimulates endometrial stromal cell decidualization. Endometrial stromal cells were obtained from normal menstruating patients with uterine myoma at hysterectomy. Stromal cells were cultured for up to 4 weeks with estradiol (E(2)) and/or medroxy progesterone acetate (MPA) in the presence or the absence of IGFBP-1 and, LR(3)-IGF-I (an IGF-I analogue) that binds to the IGF-I receptor but has reduced affinity for IGFBPs. Decidualization of endometrial stromal cells was evaluated by morphological changes and PRL release into culture media. The binding of IGFBP-1 to endometrial cells was analysed using a biosensor. MPA and E(2) induced decidualization of stromal cells, while LR(3)-IGF-I inhibited decidualization by MPA and E(2) as well as PRL and IGFBP-1 secretion into medium. IGFBP-1 induced decidualization of stromal cells in the absence of MPA and E(2) in the medium. IGFBP-1-induced decidualization was not inhibited by the addition of LR(3)IGF-1 but was inhibited by the addition of an RGD peptide, however, the RGD peptide had no effect on decidualization when added alone. The binding analysis showed that IGFBP-1 bound to the surface of endometrial stromal cells and an anti-alpha5beta1 integrin antibody inhibited its binding. These results suggest that IGFBP-1 produced by endometrium can mediate progesterone-induced decidualization possibly by interacting with alpha5beta1 integrin on the surface of endometrial stromal cells.

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MeSH descriptors

Endometrium Insulin-Like Growth Factor Binding Protein 1 Integrin alpha5beta1 Stromal Cells Cells, Cultured Endometrium Endometrium Endometrium Estradiol Estradiol Female Humans Insulin-Like Growth Factor Binding Protein 1 Integrin alpha5beta1 Integrin alpha5beta1 Medroxyprogesterone Acetate Medroxyprogesterone Acetate Prolactin Prolactin Protein Binding

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