The Incidence and Clinical Impact of Adenomyosis

In: Adenomyosis · 2021 · pp. 1–3 · doi:10.1007/978-981-33-4095-4_1 · W3131978725
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Adenomyosis incidence varies widely due to diagnostic challenges but is related to patient age, pregnancy history, and pelvic endometriosis.

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This chapter reviews evidence on the incidence and clinical impact of adenomyosis, noting that advances in imaging increase diagnoses of asymptomatic cases. It summarizes reported population estimates, including an Italy healthcare-institute study in reproductive-age women (incidence 0.02–0.03%, prevalence 0.17%) and a US cohort study (10-year incidence about 1% for ages 16–60), with differences by race. The chapter emphasizes that incidence and prevalence vary widely, potentially due to selection bias related to surgical diagnosis, lack of histological diagnostic criteria consensus affecting reproducibility, and increased MRI/ultrasound use without histological confirmation. It also states that adenomyosis incidence is related to age, number of pregnancies, and pelvic endometriosis; relevance to endometriosis: the paper explicitly notes this relationship, though its main focus is adenomyosis incidence and clinical impact rather than endometriosis itself.

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Abstract

With the advancement of imaging technology, such as ultrasound, more and more patients with asymptomatic adenomyosis are diagnosed, so the incidence of adenomyosis is higher than traditionally thought [1]. An epidemiological study from healthcare institutes in Italy had found that the incidence of adenomyosis in women of reproductive age was 0.02–0.03%, and the prevalence was 0.17% [2]. A cohort study in the United States observed 330,000 women for 10 years and found that the total incidence of adenomyosis in women aged 16–60 years was 1%. The study also found that black women had the highest incidence, while Asian women had the lowest incidence, and white women were somewhere in between [3]. From the literature, there were wide variations in the incidence and prevalence of adenomyosis, and it might be due to the difficulties in accurately assessing the incidence [4–6]. Firstly, there was selection bias in women with indications for a hysterectomy or surgery when this disease was being diagnosed. Secondly, there was a lack of consensus of histological criteria to diagnose adenomyosis, raising concerns about the reproducibility of its histological diagnosis. Thirdly, the increasing use of MRI or ultrasound imaging on symptomatic patients to diagnose this disease without histological confirmation contributed to the increasing incidence in the general population. Nevertheless, the incidence of adenomyosis is related to the patient’s age, the number of pregnancy, and pelvic endometriosis. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

Peric H, Fraser I. The symptomatology of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006;20(4):547–55. Morassutto C, et al. Incidence and estimated prevalence of endometriosis and adenomyosis in Northeast Italy: a data linkage study. PLoS One. 2016;11(4) Onchee Y, et al. Adenomyosis incidence, prevalence and treatment: United States population – based study 2006–2015. Am J Obstet Gynecol. 2020;223(1):94.e1–94.e10. Chrysostomou M, et al. Incidence of adenomyosis uteri in a Greek population. Acta obstetricia et gynecologica Scandinavica. 1991;70(6):441–4. Raju GC, et al. Adenomyosis uteri: a study of 416 cases. Aust N Z J Obstet Gynaecol. 1988;28(1):72–3. Bird CC, McElin TW, Manalo-Estrella P. The elusive adenomyosis of the uterus—revisited. Am J Obstet Gynecol. 1972;112(5):583–93. Naftalin J, et al. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 2012;27(12):3432–9. Gordts S, Grimbizis G, Campo R. Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis. Fertil Steril. 2018;109(3):380–388.e1. Harada T, et al. The impact of adenomyosis on women’s fertility. Obstet Gynecol Surv. 2016;71(9):557. Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. About this chapter Cite this chapter Fan, Z. (2021). The Incidence and Clinical Impact of Adenomyosis. In: Xue, M., Leng, J., Wong, F. (eds) Adenomyosis. Springer, Singapore. https://doi.org/10.1007/978-981-33-4095-4_1 Download citation DOI: https://doi.org/10.1007/978-981-33-4095-4_1 Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-33-4094-7 Online ISBN: 978-981-33-4095-4 eBook Packages: MedicineMedicine (R0)

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