Expression Profiling of TGF-β Receptor and its Relation with Endometriosis

Soma Ghoshal, Nisha Agrawal, Kiran Singh
In: International Journal of Infertility & Fetal Medicine · 2015 · vol. 6(3) , pp. 112–117 · doi:10.5005/jp-journals-10016-1112 · W2906571599
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Transforming growth factor-beta receptor levels were significantly downregulated in endometriotic tissues compared to controls, suggesting a potential genetic basis for endometriosis pathophysiology and therapy.

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Abstract

ABSTRACT Study objectives To measure the transforming growth factorbeta (TGF-β) receptor level in endometriotic tissues in patients selected for surgery in our hospital; and thus to assess its genetic basis in the pathophysiology of endometriosis; and to study its possibility as a potent tissue marker. Design Observational study (case control study) involving Genetic Laboratory Study. Setting Tertiary Care Institute, Gynecology Department. Population or sample Total 100 female patients undergoing surgery in our hospital involved; out of them 50 were cases and 50 controls. Materials and methods Fifty cases (having endometriosis) and 50 controls (without endometriosis) were taken. During surgery, excised specimen was examined for presence of any endometriotic tissue. The endometrial tissue samples from suspected area were taken and put immediately in RNA-PCR media and sent to Genetics Laboratory where semi-quantitative RT-PCR analysis of TGF-beta was done using primers designed by Primer Blast software (National Center for Biotechnology Information). Main outcome measures The mean TGF-β receptor level was 0.5886 in cases and the mean TGF-β receptor level in controls was 2.076. Both in extrauterine endometriosis and in adenomyosis, TGF-β receptor was downregulated equally in 80% of cases. Results Transforming growth factor-beta receptor levels in all types of endometriosis showed a significant down regulation in maximum number of cases. Conclusion This downregulation of TGF-β receptor level in the endometriotic tissues not only helps in understanding the pathological basis of endometriosis but most importantly, it can be utilized as genetic basis of therapy in endometriosis in near future. How to cite this article Ghoshal S, Agrawal NR, Singh K. Expression Profiling of TGF-β Receptor and its Relation with Endometriosis. Int J Infertil Fetal Med 2015;6(3):112-117. Consent Taken from all the 100 patients involved.

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endometriosisadenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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