The Association between ABO and Rh Blood Groups and Risk of Endometriosis in Iranian Women.

Malekzadeh F, Farideh Malekzadeh, Ashraf Moini, Moini A, Amirchaghmaghi E, Elham Amirchaghmaghi, Leila Daliri, Daliri L, Mohammad Reza Akhoond, Mehrak Talebi, Talebi M, Hosseini R, Rihaneh Hosseini
International journal of fertility & sterility · 2018 · vol. 12(3) , pp. 213–217 · doi:10.22074/ijfs.2018.5435 · PMID:29935066 · PMC6018177 · W3014564770
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This case-control study found no significant association between ABO or Rh blood groups and the risk or severity of endometriosis in Iranian women.

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This case-control study investigated whether ABO and Rh blood group distributions differ between Iranian women diagnosed with endometriosis and control women without endometriosis, using diagnostic laparoscopy at two referral infertility centers in Tehran between 2013 and 2014. Among 433 participants (213 with endometriosis and 220 controls), O and Rh+ were the most frequent blood groups, but statistical analyses using chi-square tests and logistic regression found no significant association between ABO (P=0.091) or Rh (P=0.55) blood groups and endometriosis risk. The study also reported no significant differences in ABO or Rh distributions by endometriosis stage, and no correlation with disease severity. This paper is centrally about endometriosis—its main focus is testing whether ABO and Rh blood groups are associated with endometriosis risk and severity in Iranian women.

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Abstract

BACHGROUND: Endometriosis is a common gynaecological disease that affects quality of life for women. Several studies have revealed that both environmental and genetic factors contribute to the development of endometriosis. The aim of this study was to investigate the distribution of ABO and Rh blood groups in Iranian women with endometriosis who presented to two referral infertility centers in Tehran, Iran. MATERIALS AND METHODS: In this case-control study, women who referred to Royan Institute and Arash Women's Hospital for diagnostic laparoscopy between 2013 and 2014 were assessed. Based on the laparoscopy findings, we categorized the women into two groups: endometriosis and control (women without endometriosis and normal pelvis). Chi-square and logistic regression tests were used for data analysis. RESULTS: In this study, we assessed 433 women, of which 213 patients were assigned to the endometriosis group while the remaining 220 subjects comprised the control group. The most frequent ABO blood group was O (40.6%). The least frequent blood group was AB (4.8%). In terms of Rh blood group, Rh+ (90.1%) was more frequent than Rh- (9.9%). There was no significant correlation between ABO (P=0.091) and Rh (P=0.55) blood groups and risk of endometriosis. Also, there was no significant difference between the two groups with regards to the stage of endometriosis and distribution of ABO and Rh blood groups (P>0.05). CONCLUSION: Although the O blood group was less dominant in Iranian women with endometriosis, we observed no significant correlation between the risk of endometriosis and the ABO and Rh blood groups. Endometriosis severity was not correlated to any of these blood groups.
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International Journal of Fertility and Sterility (Oct 2018) The Association between ABO and Rh Blood Groups and Risk of Endometriosis in Iranian Women Abstract Background Endometriosis is a common gynaecological disease that affects quality of life for women. Several studies have revealed that both environmental and genetic factors contribute to the development of endometriosis. The aim of this study was to investigate the distribution of ABO and Rh blood groups in Iranian women with endometriosis who presented to two referral infertility centers in Tehran, Iran. Materials and Methods In this case-control study, women who referred to Royan Institute and Arash Women’s Hospital for diagnostic laparoscopy between 2013 and 2014 were assessed. Based on the laparoscopy findings, we categorized the women into two groups: endometriosis and control (women without endometriosis and normal pelvis). Chi-square and logistic regression tests were used for data analysis. Results In this study, we assessed 433 women, of which 213 patients were assigned to the endometriosis group while the remaining 220 subjects comprised the control group. The most frequent ABO blood group was O (40.6%). The least frequent blood group was AB (4.8%). In terms of Rh blood group, Rh+ (90.1%) was more frequent than Rh- (9.9%). There was no significant correlation between ABO (P=0.091) and Rh (P=0.55) blood groups and risk of endometriosis. Also, there was no significant difference between the two groups with regards to the stage of endometriosis and distribution of ABO and Rh blood groups (P > 0.05). Conclusion Although the O blood group was less dominant in Iranian women with endometriosis, we observed no significant correlation between the risk of endometriosis and the ABO and Rh blood groups. Endometriosis severity was not correlated to any of these blood groups. Keywords

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