Effect of prepregnancy anti-inflammatory diet on pregnant women with endometriosis: The Japan Environment and Children’s Study

Hyo Kyozuka, Hidekazu Nishigori, Tsuyoshi Murata, Toma Fukuda, Akiko Yamaguchi, Aya Kanno, Shun Yasuda, Akiko Satô, Yuka Ogata, Masahito Kuse, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Keiya Fujimori
In: Authorea, Inc. · 2020 · doi:10.22541/au.158991640.07639457 · W3126459784
Observational preprint OA: gold CC0
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-11 ⓘ

In women with endometriosis, a prepregnancy anti-inflammatory diet was associated with reduced risk of very preterm birth and very low birth weight, particularly for those conceiving without assisted reproductive technology.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objective: To investigate the correlation of prepregnancy dietary inflammatory index (DII) with obstetric outcomes in women with endometriosis. Design: Prospective cohort study Setting: Japan Population: We identified 88,398 Japanese women (n=85,149 without endometriosis and n=3,249 with endometriosis) who were recruited in the Japan Environment and Children’s study (JECS) between January 2011 and March 2014. Methods: Participants were categorised according to DII quintiles (Q1 and Q5 were the most pro-inflammatory and most anti-inflammatory groups, respectively) and stratified according to the presence or absence of endometriosis. Women with endometriosis were further categorised based on conceptions after assisted reproductive technology. Main outcomes were preterm birth (PTB) and low birth weight (LBW) infant. A multiple logistic regression model was used to estimate the effect of anti-inflammatory diet on PTB before 37 or 34 weeks and LBW <2500 g or 1500 g. Results: In women with endometriosis without ART, Q5 significantly decreased the risk of PTB before <34 weeks (aOR 0.25, 95% CI 0.07–0.83) and LBW <1500 g (aOR 0.07, 95% CI 0.01–0.60). Conclusions: This study suggested a distinctive effect of anti-inflammatory diet on more severe obstetrics outcomes, specifically PTB before 34 weeks and LBW <1500 g, among women with endometriosis. Moreover, preconception lifestyle may improve perinatal mortality and morbidity among women with endometriosis. Funding: None

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK