Journal of assisted reproduction and genetics

PURPOSE: To evaluate the impact of trigger types in Gonadotropin-releasing hormone (GnRH) antagonist IVF-ICSI cycles on embryo morphokinetics and top-quality embryo production. METHODS: Retrospective cohort study of GnRH-antagonist IVF-ICS…

BACKGROUND: Infertility affects millions globally, with significant social, emotional, and economic consequences. While frozen-thawed embryo transfer (FET) is a cornerstone of assisted reproductive technology, its clinical pregnancy success…

PURPOSE: This study aims to establish a single-time point RNA-sequencing-based endometrial receptivity test (rsERT) to provide hourly precision of endometrial WOI for patients with recurrent implantation failure (RIF). METHODS: A two-phase…

PURPOSE: To identify the impact of the duration of the embryo transfer procedure on pregnancy outcomes. METHODS: This was a retrospective cohort study at a single center including single euploid frozen embryo transfers from April to Decemb…

PURPOSE: To determine factors associated with embryo disposition decisions at a large academic fertility center. METHODS: We performed a single-center retrospective cohort study of patients who made final embryo disposition (discard or don…

Since the birth of the first infant conceived through assisted reproductive technology (ART) in 1978, over 10 million individuals worldwide have been born using these methods. ART has offered hope to many facing infertility. However, concer…

PURPOSE: Fertility preservation in women with cancer represents a major medical challenge at the intersection of oncological and reproductive concerns. With therapeutic advancements, the survival rates of cancer patients have significantly …

PURPOSE: Cell-free mitochondrial DNA (cf-mtDNA) has emerged as a promising non-invasive method to predict embryo implantation potential. This study presents the first sequencing of cf-mtDNA in follicular fluid, aiming to explore the impact …

PURPOSE: To investigate any correlation between the outcomes of the first euploid frozen-thawed blastocyst embryo transfer (FBT) and the subsequent euploid FBT derived from sibling oocytes. METHODS: This retrospective study analyzed data f…

PURPOSE: To study the global, regional and national burden and trend of primary and secondary infertility, by sex and sociodemographic index (SDI), over the period 1990-2021. METHODS: Data on the prevalence and disability-adjusted life yea…

PURPOSE: In China, the prevalence of hepatitis B virus (HBV) infection among infertile couples is a significant clinical problem. It is necessary to determine the effect of HBV infection on embryo development. METHODS: The 4301 fresh cycle…

PURPOSE: This research sought to investigate if a physician's experience of an embryo transfer (ET) correlates to rates of success. METHODS: A single experienced physician rated characteristics of ETs including ease of transfer (1-10), vis…

BACKGROUND: Zona pellucida (ZP) plays an important role in oocyte development and fertilisation, as well as in early embryo development. However, there is currently no exploration of systematic categorising and clinical treatment measures f…

PURPOSE: To screen drug targets of ovarian aging from a genetic perspective. METHODS: Systematic analyses were conducted with cis-expression quantitative trait loci data of druggable genes extracted as instrument variables. Summary statist…

PURPOSE: Endometriosis (EM) and recurrent spontaneous abortion (RSA) exhibit clinical associations, yet their shared molecular mechanisms remain unclear. This study aimed to identify shared molecular mechanisms and potential hub genes under…

PURPOSE: To evaluate whether prior SARS-CoV-2 infection adversely affects live birth and perinatal outcomes following subsequent frozen-thawed embryo transfer (FET) and to further investigate whether the time interval between infection and …

INTRODUCTION: Time-lapse technology enables recording embryo morphokinetic parameters, which are associated with embryonic competence and assisted reproductive technology (ART) outcomes. While female factors such as age and BMI are known to…

PURPOSE: To investigate the impact of first-trimester COVID-19 infection on the perinatal and obstetric outcomes following in vitro fertilization-frozen embryo transfer. METHODS: This retrospective study was conducted at a university-affil…

PURPOSE: To evaluate whether the inflammatory proteomics of uterine fluid is feasible in defining the endometrial receptivity phase. METHODS: Inflammatory proteomics of uterine fluid was measured using the OLINK Target-96 Inflammation pane…

PURPOSE: To assess whether in-office intraovarian PRP injections among patients with a history of a low euploid embryo yield following freeze-all PGT-A IVF cycle improves transferable embryo yield when compared to controls. MATERIALS AND M…

PURPOSE: This study aims to characterize assisted reproductive technology patients' online discussions of fertility supplements to better understand how this audience uses supplements, their attitudes toward perceived effects of the supplem…

PURPOSE: To evaluate live birth rates per embryo transfer where the primary indication for assisted reproduction was preimplantation genetic testing for monogenic conditions. METHODS: All oocytes were fertilized using intracytoplasmic sper…

PURPOSE: This study aimed to compare the pregnancy outcomes of letrozole (LE)-induced ovulation and hormone replacement treatment (HRT) in endometrial preparation for frozen embryo transfer (FET) in women with polycystic ovary syndrome (PCO…

PURPOSE: To assess the long-term outcomes of MR-guided focused ultrasound (MRgFUS) for treating uterine fibroids, focusing on re-intervention rates, pregnancy outcomes, and the onset of menopause over a 7-year follow-up period. MATERIALS A…

The objective of this study is to evaluate if medical treatment before assisted reproductive technology (ART) improves the results in infertile patients with adenomyosis. A literature search was performed with EMBASE, PubMed, and Cochrane. …