Journal of assisted reproduction and genetics

The 8 th International Congress of the ISFP was held in Tokyo, Japan, from November 15 to 17, 2024. The theme of this year's Congress was "Rethinking Personalized Fertility Preservation and Cancer Survivors-Opening a New Frontier". The cong…

PURPOSE: To investigate the effects of microplastics (MPs) on the human endometrium in vitro. METHODS: A predictive 3D endometrial in vitro model was generated using highly porous scaffolds where human endometrial stromal (hESC) and epithe…

BACKGROUND: The aim of this study was to investigate the role of miR-361-5p (a tumor suppressor) in regulating granulosa cell function by targeting SLC25A24, a key mitochondrial protein, to uncover potential therapeutic targets for diminish…

PURPOSE: To assess national trends, characteristics, and delivery outcomes associated with gestational carriers (GC) pregnancies. METHODS: This cross-sectional study queried the Healthcare Cost and Utilization Project's National Inpatient …

PURPOSE: To examine levels of patient engagement in fertility care by evaluating the association between initial visit type (in-person versus telehealth) and discharge with an ongoing pregnancy. METHODS: Retrospective study of all new pati…

Polycystic ovary syndrome (PCOS) is an endocrine-gynaecological disorder characterized by hyperandrogenism and menstrual irregularity or ovarian cyst. The onset of PCOS involves a complex interplay among various factors such as genetics, ep…

Infertility affects a significant portion of couples globally. In vitro fertilization (IVF) is a widely utilized assisted reproductive technology (ART). Despite significant advancements, IVF success rates remain suboptimal, which necessitat…

PURPOSE: This study identified novel variants of the FSIP2 and SPEF2 genes in multiple morphological abnormalities of the sperm flagella (MMAF) patients and to investigate the potential effect of variations on male infertility and assisted …

PURPOSE: Map the nuclear error phenotypes in the two-cell embryo after assisted reproduction using time lapse images and the effect on good quality blastocyst formation. METHODS: Retrospective cohort study using time lapse images, categori…

Gender affirming hormone therapy may be used to relieve dysphoria among transgender or gender-diverse individuals. However, the long-term effects of these treatments on reproductive health remain uncertain. Before initiating hormone therapy…

PURPOSE: This study aimed to identify demographic and clinical factors associated with low maturation rates and to investigate if the rate of immature oocytes impacts the outcomes of mature sibling oocytes. METHODS: Women undergoing their …

PURPOSE: Selection of optimal embryo transfer strategies for IVF patients treated with antagonist protocols. METHODS: A retrospective study was conducted to assess whether whole embryo culture to the blastocyst stage could enhance the cumu…

PURPOSE: The impact of oral GnRH antagonists on IVF treatment outcomes remains unclear. The aim of the study is to investigate the impact of GnRH antagonist over the outcomes of IVF. METHODS: We performed an electronic search using MEDLINE…

PURPOSE: This study aimed to evaluate the long-term impact of mild COVID-19 infection and COVID-19 vaccination on ovarian function in patients undergoing assisted reproductive technology (ART). Specifically, we assessed ovarian outcomes bet…

PURPOSE: Optimal endometrial preparation is essential for the transfer of a euploid embryo. Recent works have shown advantages of ovulatory cycle frozen-thawed embryo transfer (Ovu-FET) for simplicity, implantation rate, and reduction of hy…

PURPOSE: Assisted reproductive technology (ART) procedures are associated with placental dysfunction involving dysregulation of several molecular factors and pathways. MicroRNAs (miRNAs) are crucial epigenetic regulators involved in placent…

PURPOSE: Natural dizygotic twinning (DZT) results from hyper-ovulation and is an indicator of female fertility. However, some traits linked to DZ twinning are also associated with infertility. We examined the relationship between DZT and fe…

PURPOSE: Women with polycystic ovary syndrome (PCOS) show greater heterogeneity in ovarian responses during ovarian stimulation. We aimed to investigate the potential predicting factors among individualized basic parameters that affect poor…

OBJECTIVE: To study if the transfer of warmed blastocysts without blastocoele re-expansion is effective and safe. METHODS: Three thousand one hundred ninety-six frozen-thawed single blastocyst transfer cycles were conducted. The embryos we…

PURPOSE: To study whether mid-luteal endometrial B-cell lymphoma 6 (BCL6) or sirtuin-1 (SIRT1) immunostaining in an ovarian stimulation (fresh) in vitro fertilization (IVF) cycle was predictive of risk for endometriosis. Additionally, to ev…

PURPOSE: Human papillomavirus (HPV), the most common sexually transmitted infection, has been proposed as a potential factor in male infertility. This study aimed to assess the prevalence of HPV in semen samples from men undergoing in vitro…

BACKGROUND: Sequential embryo transfer (SEQET) can increase the availability of embryos at various stages within the implantation window, thus improving the outcomes of assisted conception. This research seeks to analyze and synthesize clin…

PurposeThis study aims to summarize and analyze the existing research on anxiety and depression within the field of assisted reproduction technology, exploring current hotspots, emerging frontiers, and trends, while offering insights for fu…

PURPOSE: Spermatozoa centriolar defects can result in abnormal zygote functions. Recently, a method to quantify spermatozoa centriolar defects was developed named Fluorescence-Based Ratiometric Analysis of Sperm Centrioles (FRAC). However, …

PURPOSE: This study aimed to explore the roles of spermatozoal sialidase NEU1 and NEU3 in affecting the fertilization rate of in vitro fertilization (IVF), and whether sperm sialidase NEU1 and NEU3 can be used as predictors of IVF outcome. …