New England Journal of Medicine

Treatment with nafarelin, a gonadotropin-releasing hormone agonist, reversibly inhibits ovarian function and induces hypoestrogenemia. To determine the efficacy of such hormonal manipulation in the treatment of endometriosis, we randomly as…

Presentation of CaseA 36-year-old woman was admitted to the hospital because of a pelvic mass.Seven years earlier a total abdominal hysterectomy was performed elsewhere because of pelvic pain of five days' duration and the finding of an enl…

Endometriosis is the presence of tissue resembling endometrial glands and stroma outside the uterus. The anatomical sites most often affected by endometriosis are the ovaries, uterosacral ligaments, pelvic peritoneum, rectovaginal septum, c…

The murine monoclonal antibody OC 125 reacts with an antigen (CA 125) common to most nonmucinous epithelial ovarian carcinomas. An assay has been developed to detect CA 125 in serum. By this assay, only 1 per cent of 888 apparently healthy …

We analyzed a two- to seven-year follow-up of 1145 infertile couples to determine the frequency of pregnancy occurring independently of treatment. Pregnancy occurred in 246 of 597 treated couples (41 per cent) and in 191 of 548 untreated co…

The cost effectiveness of estrogen use in postmenopausal women was analyzed with use of data from the medical and epidemiologic literature. Risks of endometrial cancer, uterine bleeding, and gallbladder disease were weighed against benefits…

ESTROGEN and progesterone have long stood as the sole controlling agents in the growth of the endometrium, and both agents have long been available for therapeutic purposes in the form of chemically modified preparations of high potency. It…

The uteri of 379 women over 50 years of age were studied at autopsy; endometrial hemorrhage, with or without necrosis, was found in 19. These postmenopausal patients had no evidence of hormonal abnormalities that could have given rise to a …