Scientific reports

The impact of endometrioma size on ovarian reserve remains controversial. Although endometriomas are known to reduce anti-Müllerian hormone (AMH) levels, some studies suggest a paradoxical association between larger cysts and higher AMH. Th…

This study investigates the molecular mechanism by which USP25 contributes to pancreatic microcirculatory disturbance in severe acute pancreatitis (SAP). SAP was induced by retrograde injection of 4% sodium taurocholate into the pancreatic …

This study investigated whether thromboelastography (TEG) parameters on the day of embryo transfer, alone or combined with other clinical indicators, could predict early pregnancy loss in in vitro fertilization (IVF)/intracytoplasmic sperm …

Sexually transmitted infections (STIs) are a global public health concern, particularly among women of reproductive age and leads to severe health complications. Married women, despite being perceived as low-risk, are often excessively affe…

Profound Intellectual Multiple Disability (PIMD)/Polyhandicap, thanks to advances in medical management, are now reaching adulthood and have increased survival. Although, ten percent of the adults are cared for in paediatric facilities. The…

Hashimoto's disease is a thyroid disorder characterized by elevated antibody levels and altered gland structure seen on ultrasound. It is a common autoimmune disease, primarily affecting women. The disease has both physical and psychologica…

Accurate and reproducible phenotyping is essential for large-scale biomedical research. However, developing robust phenotype definitions in biobanks is challenging due to diverse data sources and varying medical ontologies. As a result, the…

The fibrosis mechanism in endometriosis is not elucidated. We investigated the role of eosinophil in fibrosis of endometriosis. The endometriotic stromal cells (ESCs) and endometrial epithelial cells (EECs) were subjected to in vitro experi…

Sepsis represents a significant global health challenge, necessitating early detection and effective treatment for improved outcomes. While traditional inflammatory markers facilitate the diagnosis of sepsis, the aspect of immune suppressio…

Endometriosis with ovarian cysts is common in reproductive-age women and contributes to pain and infertility. The influence of age on clinical and surgical outcomes remains uncertain. This retrospective study analyzed 994 patients diagnosed…

The synchronized beating of ciliated cells within the human fallopian tube is crucial for the transport of the oocyte and the early embryo. To date, the precise effects of age, lifestyle, and disease on ciliary beating in the human fallopia…

Little is known about how exclusive e-cigarette use affects exosomal microRNA (miRNA) expression, which is crucial in inflammation and disease processes like cancer. We compared exosomal miRNA profiles between exclusive e-cigarette users an…

Endometriosis (EMs) is a chronic disease affecting millions of women worldwide, yet its pathogenesis remains unclear, and current diagnostic methods are limited. This study based on the EMs dataset from Gene Expression Omnibus (GEO), key ge…

To identify the factors affecting adverse reproductive outcomes in TPOAb-positive patients and to establish a predictive model based on these factors to assess the risk of adverse reproductive outcomes in patients. A retrospective cohort st…

In the treatment of ulcerative colitis (UC), persistent inflammatory activity increases the risk of recurrence and poor prognosis. Probe-based confocal laser endomicroscopy (pCLE) can accurately assess the UC inflammation than conventional …

Uterine Corpus Endometrial Carcinoma (UCEC) represents a common malignant neoplasm in women, with its prognosis being intricately associated with available therapeutic interventions. In the past few decades, there has been a burgeoning inte…

Opioid prescribing for patients with chronic non-cancer pain is common despite issues associated with long-term efficacy, functional improvement, and safety. Pain specialists assess many patients with chronic non-cancer pain, but their expe…

Resilience is a dynamic process involving the interaction of multi-systemic individual and environmental factors that operate to protect against adversity and promote positive personal outcomes. Resilience is a topic of interest among group…

In Japan, cancer screening is conducted under a variety of umbrellas, i.e., via population-based screening, occupational health checkups, insured medical care, and personal medical checkups. Quality control assessment of cancer screenings i…

In Europe, endometrial carcinoma was found to be the fourth most common tumor in the female population in 2022. The depth of myometrial invasion is a well-established and crucial prognostic risk factor in endometrial cancer patients and is …

Few studies explored air pollution's role in female infertility, especially with temperature factors. Investigating these effects is essential given global climate change and declining fertility rates. This retrospective study, conducted in…

Biological aging clocks capture heterogeneous rates of aging in individuals and transform current medical practice toward translational preventive medicine. Here, we developed a clinical aging clock based on routine blood biochemistry marke…

Diminished ovarian reserve, linked to reduced fertility and adverse reproductive outcomes, can be influenced by a number of modifiable factors while it's not clearly known that whether the quality of beverage intake can affect ovarian reser…

Endometriosis is a prevalent chronic inflammatory disease in women, which may advantage from potential lifestyle strategies for prevention, modification, or treatment of the condition. The aim of the current study was to evaluate the associ…

The diagnosis rate of chronic endometritis (CE), closely associated with infertility, recurrent pregnancy loss, and recurrent implantation failure, remains low in clinical practice. The monocyte percentage (MP) has been identified as a biom…