Fertility and sterility

We describe an unusual case of ascites caused by the rupture of a large endometrioma.

OBJECTIVE: To examine women's emotional responses to learning the diagnosis of premature ovarian failure (POF) and identify the sources of support used for coping. DESIGN: Observational study. SETTING: National Institutes of Health Clinic…

OBJECTIVE: An association between assisted reproductive technique (ART) and specific imprinting mutations, such as Beckwith-Wiedemann syndrome (BWS), has recently been documented. Based on experiments in farm animals that demonstrated an as…

OBJECTIVE: [1] To examine the effects of body mass index (BMI), age, cigarette smoking, cause of infertility, and use of oral contraceptives on baseline serum testosterone (T), and [2] to examine associations between baseline serum T and IV…

OBJECTIVE: To determine whether body size and perceived figure, both current and historical, are associated with a diagnosis of endometriosis on laparoscopy. DESIGN: Cohort study of consecutively identified patients undergoing laparoscopy …

OBJECTIVE: To investigate whether separated and cultured endometriotic and endometrial stromal and epithelial cells release urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and soluble plasminogen activator …

OBJECTIVE: To compare health-related quality of life (HRQoL) after bipolar radio frequency ablation and thermal balloon ablation in women with dysfunctional uterine bleeding. DESIGN: Randomized clinical trial. SETTING: Teaching hospital. …

The role of surgery vs. IVF-embryo transfer to improve the potential for conception will vary as enhancements of these interventions occurs. Well-designed and conducted studies, controlling for the complexities of surgical trials are needed…

OBJECTIVE: To determine the changes in cytokine levels from women with endometriomas who are treated with recombinant interleukin-2 after ultrasound-guided cyst aspiration, and to relate these changes to the clinical results observed in the…

OBJECTIVE: To estimate regulatory cytokine synthesis and lymphocyte activation in the peripheral blood and endometrial tissue of patients with endometriosis. DESIGN: Controlled clinical study. SETTING: Medical center. PATIENT(S): Fifteen…

OBJECTIVE: Follow-up of IVF/intracytoplasmic sperm injection (ICSI) patients to obtain accurate information concerning chances of live birth as well as early treatment dropout. Comparison of the cumulative pregnancy rates, established in co…

Endometriosis is classically defined as ectopic growth of endometrial glands and stroma. Currently, histologic confirmation of laparoscopic findings is paramount for diagnosis of endometriosis and evidence is evolving suggesting that the pa…

OBJECTIVE: To obtain histologic confirmation of lesions suspected of endometriosis at laparoscopy. DESIGN: Prospective clinical study. SETTING: Patients in an academic hospital. PATIENT(S): Women of reproductive age who complained of chr…

Matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-9 expression with real-time quantitative polymerase chain reaction were analyzed in endometriotic and nonendometriotic ovarian cysts. Although MMP-1 was not detected, MMP-9 and MMP-2 were e…

OBJECTIVE: To investigate differentially expressed genes in epithelial and stromal cells of eutopic endometrium from patients with deep endometriosis and women with normal pelvic cavities using laser capture microdissection and complementar…

To explore the initial activity of endometrial stromal cells (ESCs) and the participation of monocyte chemoattractant protein-1 (MCP-1) in the histogenesis of endometriosis, vascular endothelial growth factor (VEGF) secretion of ESCs and th…

OBJECTIVE: To study the effect of letrozole (Let) and anastrozole (Anas) on apoptosis and cell proliferation in epithelial endometrial cells (EEC) from patients with endometriosis (EDT). DESIGN: Prospective study. SETTING: Research instit…

OBJECTIVE: To assess histologic damage and functional impairment following coaxial tubal catheterization. DESIGN: Prospective randomized controlled study. SETTING: Research laboratory. PATIENT(S): Ninety-two female New Zealand rabbits. …

OBJECTIVE: To study the apparent association between interstitial fallopian tube polyps and isthmic tubal dilatation. DESIGN: Retrospective clinical study. SETTING: Tertiary academic medical center. PATIENT(S): Sixty-five patients with n…

OBJECTIVE: To investigate the role of interleukin (IL)-16 in peritoneal fluid in the pathogenesis of endometriosis. DESIGN: Comparative and laboratory study. SETTING: University of Tokyo Hospital. PATIENT(S): Peritoneal fluids (PFs) were…

OBJECTIVE: To evaluate the concentrations of macrophage migration inhibitory factor (MIF) in the peripheral blood of normal women and patients with endometriosis. DESIGN: Retrospective study using ELISA to measure peripheral blood MIF. SE…

Two recent studies reported in this issue of Fertility and Sterility have explored important issues regarding the understanding and diagnosing of endometriosis. These studies emphasize the complexity of endometriosis and underscore the diff…

OBJECTIVE: To identify endometriosis as a cause of chronic pelvic pain in premenarcheal girls without an obstructive anomaly of the reproductive tract. DESIGN: A case series. SETTING: Tertiary-care academic pediatric hospital. PATIENT(S)…

OBJECTIVE: To determine whether endometriosis can be treated with the angiogenesis inhibitor endostatin and the effect of this treatment on fertility and reproduction. DESIGN: Pharmacologic intervention in a surgically induced model of end…