Frontiers in medicine

BACKGROUND: Ovarian torsion is a gynecologic emergency requiring timely management to preserve ovarian function and future fertility. Clinical presentation is heterogeneous and frequently non-specific, making the decision between operative …

BACKGROUND: Ovarian mucinous tumors are histologically classified into benign, borderline, and malignant categories, with borderline tumors generally demonstrating an intermediate prognosis. However, ovarian borderline mucinous tumors with …

OBJECTIVE: The aim of this study is to evaluate the association between parametrial invasion (PI) and systemic inflammatory indices in patients with cervical cancer, exploring whether routinely available hematological markers reflect local …

BACKGROUND: Endometriosis is a chronic inflammatory disease with immune dysregulation in which angiogenic, and hematopoietic mediators are thought to contribute to ectopic lesion establishment and persistence. Whether circulating immune cel…

Perinatal transmission of Borrelia burgdorferi sensu lato (Bb), the spirochetal agent of Lyme disease, is an issue of public health importance and research significance. This alternate mode of transmission and the potential risk of adverse …

OBJECTIVE: To compare perioperative safety, efficiency and learning curves of MPLH, RASPH and SPLH, and analyze surgical disparities stratified by uterine volume. We adopted multivariable regression (primary adjusted analysis) and multinomi…

INTRODUCTION: Mineralocorticoid receptor antagonists, spironolactone, eplerenone, and finerenone, are cornerstone therapies in cardiovascular and renal diseases. While their efficacy is established, a systematic, head-to-head comparison of …

We explored the design and preliminary findings of the Pregnancy and Rheumatoid Arthritis Registry (PRAISE-H), a Japan-wide prospective registry of reproductive-age patients with rheumatoid arthritis (RA) that captures challenges in daily l…

BACKGROUND: Relugolix, an oral gonadotropin-releasing hormone (GnRH) antagonist, represents a potentially effective and less invasive therapeutic approach for retained products of conception (RPOC). However, its impact on subsequent pregnan…

OBJECTIVE: This prospective study aimed to evaluate the clinical outcomes of a standardized surgical algorithm adopting a "vaginal-first" approach in patients with non-descensus uteri. It sought to redefine vNOTES as an "educational bridge"…

OBJECTIVE: To investigate the clinical characteristics, misdiagnosis causes, and preventive strategies of pseudo-Meigs' syndrome, and to improve clinicians' awareness of pelvic tumors presenting with pleural effusion and ascites. METHODS: …

BackgroundTraditional physiology teaching relies on 2D materials and static specimens, making it difficult to intuitively present complex anatomical structures and physiological mechanisms. 3D Intelligent Printing Technology (3DIPT) has dem…

BACKGROUND: Recurrent pregnancy loss (RPL) is a clinically and emotionally significant reproductive condition, yet its reported prevalence and etiological distribution vary widely across studies. This systematic review and meta-analysis aim…

Redox biology occupies a central but paradoxical role in human reproduction. Reactive oxygen species (ROS) are indispensable mediators of sperm capacitation, oocyte activation, embryo development, and trophoblast invasion, yet excessive ROS…

BACKGROUND: The relationship between the vascular flow index (VFI) of the endometrium and the pregnancy outcome in the frozen embryo transfer (FET) cycle remains controversial, and there is currently no recommended optimal range for VFI. O…

BACKGROUND: Spexin is a recently identified neuropeptide that modulates the hypothalamic-pituitary-gonadal axis and has been shown to regulate granulosa cell function. Although circulating spexin levels decline with age and metabolic dysreg…

BACKGROUND: Premature ovarian insufficiency (POI) is defined as loss of ovarian function before the age of 40 years. It has a profound impact on patients' quality of life, particularly due to infertility and menopausal symptoms related to e…

BACKGROUND: Uterine leiomyomas represent the most frequent benign pelvic tumors in women. Although various degenerative changes can occur, the complete cystic transformation of a submucosal leiomyoma-resulting in a large, fluid-filled intra…

Diffuse uterine leiomyomatosis is frequently misdiagnosed, highlighting the need to improve awareness and understanding of this rare condition. We report a case of a 29-year-old nulliparous woman presenting with menorrhagia who was diagnose…

BACKGROUND AND OBJECTIVE: Female-specific pain conditions such as dysmenorrhoea, endometriosis, and pain associated with pregnancy, childbirth, and menopause are highly prevalent and frequently impair quality of life. Superficial heat thera…

BACKGROUND: The key biomarkers, therapeutic targets, and pathological mechanisms of endometriosis are urgently needed to be elucidated. The role of CTSZ in EM needs to be clarified, and the potential regulatory mechanisms and corresponding …

Dysbiosis of the female genital tract microbiota represents a key pathological basis underlying clinical symptoms such as vaginal dryness and dyspareunia, which subsequently contribute to diminished sexual quality of life (QoL) in women. Al…

OBJECTIVES: To evaluate the efficacy of Honghua Ruyi Pills combined with estradiol valerate and dydrogesterone tablets in promoting endometrial repair and menstrual recovery after artificial abortion. METHODS: This was a randomized, double…

Female infertility often results from ovarian insufficiency, endometrial damage, metabolic disorders, and treatment-induced reproductive decline. The regenerative benefits of emerging stem cell-based therapies are achieved through paracrine…

OBJECTIVES: Endometrial receptivity lacks robust biomarkers. Given its role in stabilizing the progesterone receptor, the epigenetic regulator BMI1 is a key candidate, yet its clinical potential is undefined. This study aimed to characteriz…