Frontiers in medicine

BACKGROUND AND OBJECTIVE: Female-specific pain conditions such as dysmenorrhoea, endometriosis, and pain associated with pregnancy, childbirth, and menopause are highly prevalent and frequently impair quality of life. Superficial heat thera…

BACKGROUND: The key biomarkers, therapeutic targets, and pathological mechanisms of endometriosis are urgently needed to be elucidated. The role of CTSZ in EM needs to be clarified, and the potential regulatory mechanisms and corresponding …

Dysbiosis of the female genital tract microbiota represents a key pathological basis underlying clinical symptoms such as vaginal dryness and dyspareunia, which subsequently contribute to diminished sexual quality of life (QoL) in women. Al…

OBJECTIVES: To evaluate the efficacy of Honghua Ruyi Pills combined with estradiol valerate and dydrogesterone tablets in promoting endometrial repair and menstrual recovery after artificial abortion. METHODS: This was a randomized, double…

Female infertility often results from ovarian insufficiency, endometrial damage, metabolic disorders, and treatment-induced reproductive decline. The regenerative benefits of emerging stem cell-based therapies are achieved through paracrine…

OBJECTIVES: Endometrial receptivity lacks robust biomarkers. Given its role in stabilizing the progesterone receptor, the epigenetic regulator BMI1 is a key candidate, yet its clinical potential is undefined. This study aimed to characteriz…

Ovarian cancer is a malignant tumor of the female reproductive system with a high mortality rate. Currently, China has the highest number of new ovarian cancer cases worldwide; therefore, preoperative diagnosis is of particular importance. …

BACKGROUND: Endometriosis is an estrogen-dependent inflammatory disorder associated with pelvic pain, infertility, repeated treatment, and impaired quality of life. Thyroid dysfunction and thyroid autoimmunity are also common in reproductiv…

OBJECTIVE: To investigate the effect of Tiao-Jing-Cu-Yun Acupuncture on pregnancy outcomes in infertility patients with thin endometrium undergoing artificial cycle frozen-thawed embryo transfer (AC-FET). METHODS: A prospective, assessor-b…

BACKGROUND: Uterine artery embolization (UAE) is a well-established, minimally invasive treatment for symptomatic uterine fibroids. Traditionally performed through transfemoral access (TFA), there has been growing interest in the transradia…

BACKGROUND AND OBJECTIVES: Oocyte freezing can be performed for up to ten years, with regulations regarding storage duration and age limits varying by country, including a maximum age of up to 50 years in some regions. The standard method f…

BACKGROUND: To explore the initial clinical feasibility and preliminary surgical safety of transvaginal four-wall directional in-bag morcellation for extracting exceedingly large uteri during laparoscopic total hysterectomy (TLH), aiming to…

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic and multi-spectrum disease, characterized by the development of benign hamartomas in multiple organ systems, which may be misdiagnosed as malignant neoplasms. We present the …

OBJECTIVE: To investigate the diagnostic value of ultrasound in intrauterine device (IUD) embedment complicated by bladder stone formation and to discuss the clinical approach to diagnosis and management. METHODS: We retrospectively analyz…

INTRODUCTION: Extra-pelvic endometriosis is a rare and complex condition characterized by endometriotic implants located outside the pelvis. It commonly poses significant diagnostic challenges and considerable surgical management difficulti…

BACKGROUND: The increasing global incidence of endometrial cancer (EC) underscores the urgent need for effective early detection. Noninvasive detection approaches, such as transvaginal ultrasonography (TVS), frequently exhibit low specifici…

Abdominal pregnancy is a special type of ectopic pregnancy that require careful evaluation for accurate diagnosis and appropriate management. Detailed clinical presentations, surgical procedures, and histopathological examinations of five c…

BACKGROUND: Chronic endometritis (CE) is an inflammatory condition characterized by endometrial plasmacyte infiltration. The diagnosis and treatment of CE have attracted more and more attention. This article aimed to analyze the relevant ke…

INTRODUCTION: This study aimed to explore the feasibility and safety of robotic single port vaginal natural orifice transluminal endoscopic surgery (RSP-vNOTES) hysterectomy when compared with traditional vaginal natural orifice translumina…

OBJECTIVE: This study aimed to assess the efficacy of acupuncture combined with Chinese herbal medicine (CHM) on endometriosis-associated pain. METHODS: We searched eight electronic databases (PubMed, Web of Science, EMBASE, the Cochrane L…

BACKGROUND: Chronic pelvic pain (CPP) affects 15% of reproductive-aged women, with current treatments showing limited efficacy. This study evaluated whether combining acupuncture with conventional therapy improves outcomes compared to conve…

OBJECTIVE: Our study aims to establish and validate a diagnostic scoring system for distinguishing malignant cystic ovarian tumors (MCOTs) from benign cystic ovarian tumors (BCOTs). METHODS: The study population was sourced from two indepe…

INTRODUCTION: Ovarian reserve depicts the quality and quantity of oocytes remaining in the ovaries and gives an idea about ovarian function at a given time. Because of aging, ovarian reserve diminish physiologically. However, many women fac…

BackgroundAs the main cause of maternal deaths in early pregnancy, delayed diagnosis of ectopic pregnancy (EP) may lead to severe consequences. Patients with pregnancy of unknown location (PUL) exhibit a significantly higher incidence of EP…

BACKGROUND: The levonorgestrel intrauterine system (LNG-IUS) may have its contraceptive or therapeutic efficacy compromised if displacement or expulsion occurs. By suturing and securing the device to the uterine wall, the risk of expulsion …