Zhang Y

BackgroundPelvic organ prolapse (POP) significantly impacts women's quality of life, with laparoscopic sacrocolpopexy (LSC) considered the gold standard for treatment. However, LSC carries risks of complications, prompting exploration of al…

BackgroundLncRNA LINC02381 has emerged as a promising tumor biomarker; however, its involvement in the pathogenesis of pancreatic cancer remains unexplored at this time. The objective of this study is to elucidate the regulatory effect of L…

BackgroundOsteoporosis is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration of bone tissue. Our previous investigation provided preliminary evidence that single nucleotide polymorphisms (SN…

BackgroundAMH is a dependable indicator of ovarian reserve function and assessment of ovarian responsiveness. The relationship between reduced ovarian reserve and pregnancy loss remains poorly understood and requires further investigation. …

BackgroundImpaired decidualization is associated with recurrent implantation failure (RIF) and lysophosphatidic acid (LPA) is known to play an important role in decidua formation. However, the specific impact of LPA in endometrial deciduali…

BackgroundSUGT1 (Suppressor of the G2 allele of SKP1) and FH (fumarate hydratase) have recently garnered significant attention from the research community. SUGT1 functions as a molecular chaperone, regulating the stability and activity of v…

Endometriosis (EM) is a common and challenging condition of reproductive-aged women and its pathogenesis is associated with endometrial stromal cells (ESCs). This study aimed to explore the role of FOXC1 in invasion and migration of ectopic…

OBJECTIVE: Endometriosis increases ovarian cancer (OC) risk through genetic mutations, chronic inflammation, and hormonal dysregulation, yet the underlying molecular pathways remain underexplored. This study aims to identify endometriosis-a…

BackgroundEndometrial cancer (EC), a type of uterine cancer, is witnessing a global increase in incidence. Despite advancement in diagnosis and treatment, metastatic or recurrent EC often exhibits a poor prognosis, necessitating novel thera…

Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they ofte…

BackgroundComprehensive sonographic evaluation of pre- and postmenopausal women with abnormal uterine bleeding is essential for accurate diagnosis and the optimization of curative outcomes for endometrial malignancy. Microvascular flow imag…

PURPOSE: The aim of this study was to summarize and analyze the incidence, underlying causes and related risk factors of misdiagnosis in patients with Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA) syndrome. METHODS: This is …

Endometriosis (EMS) is a prevalent gynecological disease afflicting reproductive-age women, characterized by the presence of endometrial tissue outside the uterus. The clinical manifestations of this condition include pelvic pain, dyspareun…

Abstract Purpose To study the efficacy of multimodal ultrasonography in evaluating endometrial receptivity in patients presenting with various ultrasonic manifestations of adenomyosis (AM). Methods A total of 100 patients diagnosed with …

A new case of dementia is diagnosed every 3 s. Beyond age, risk prediction of dementia is challenging. There is growing evidence of underlying processes that connect aging across organ systems and may provide insight for early detection, an…

Rationale: Endometriosis, characterized by the presence of ectopic endometrial-like tissue, is a common chronic inflammatory disorder in gynecology. However, current treatments, including surgery and hormone therapy, often yield suboptimal …

ObjectiveThis study aimed to analyze the correlation between pre-pregnancy body mass index (BMI) and the risk of preterm birth (PTB) in the assisted reproductive technology (ART) population and to determine the optimal BMI associated with t…

Non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonists exhibit remarkable potency and specificity in inhibiting GnRH receptor activity. The orally administered versions of these drugs, notably elagolix and relugolix, have ob…

Fibrosis constitutes the principal pathophysiological mediator of pain and infertility manifestations in endometriosis, and the inhibitory factor of the TGF-β pathway, MADH7, makes a vital impact on the progression of fibrosis. Ovarian tumo…

BackgroundThis study assessed the impact of chronic hepatitis B virus (HBV) infection on ovarian reserve in women.MethodsWe analyzed data from 38,861 infertile women undergoing their first in vitro fertilization (IVF) treatment (2016-2022),…

BackgroundMaternal short-term outcomes of postpartum depression (PPD) were widely examined, but little is known about its long-term association with multiple chronic diseases (multimorbidity) in women's later life. This study aims to assess…

BackgroundTo investigate the optimal periendometrial zone (PEZ) in ultrasound (US) images and assess the performance of ultrasound radiomics in predicting the outcome of frozen embryo transfer (FET).MethodsThis prospective study had 422 fem…

BACKGROUND: To evaluate maternal and perinatal outcomes in women with different adenomyosis phenotypes and to assess the impact of placental attachment site in patients with intrinsic adenomyosis. METHODS: This retrospective cohort study a…

BackgroundPreimplantation genetic testing for chromosomal structural rearrangements (PGT-SR) has been widely utilized to select euploid embryos in patients carrying balanced chromosomal rearrangements (BCRs) by chromosome copy number analys…

BackgroundThe effect of pre-pregnancy intrauterine device (IUD) use on subsequent preterm birth (PTB) remains unclear. We aim to investigate the association between IUD use before pregnancy and subsequent PTB.MethodsA total of 240,437 women…