Mechanism of FOXC1 in the invasion and migration of ectopic endometrial stromal cells in endometriosis

Rui Huang, Xiaobin Li, Yan Li, Yun Zhang
Pflugers Archiv : European journal of physiology · 2025 · vol. 478(1) , pp. 9 · doi:10.1007/s00424-025-03137-w · PMID:41387579 · W4417289247
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

FOXC1 promotes ectopic endometrial stromal cell invasion and migration by upregulating IGF2BP3 and stabilizing ITGB1 mRNA in an m6A-dependent manner.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the role of FOXC1 in invasion and migration of ectopic endometrial stromal cells in endometriosis by comparing human eutopic versus ectopic ESCs and measuring FOXC1, IGF2BP3, and m6A-related regulation of ITGB1. In ectopic ESCs, FOXC1 downregulation inhibited invasion and migration, while FOXC1 was reported to bind the IGF2BP3 promoter to increase IGF2BP3 expression and to promote ITGB1 transcription and ITGB1 mRNA stability in an m6A-dependent manner. Overexpression of IGF2BP3 or ITGB1 attenuated the inhibitory effects of FOXC1 knockdown, supporting the proposed FOXC1–IGF2BP3–ITGB1 pathway. This paper is centrally about endometriosis — it focuses on FOXC1-driven mechanisms that promote ectopic endometrial stromal cell invasion and migration via IGF2BP3 and m6A-dependent ITGB1 regulation.

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endometriosis

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