Yingfang Zhou

BACKGROUND: This study aimed to investigate potential factors, especially early-life exposures, associated with endometrioma (OMA) and/or deep infiltrating endometriosis (DIE) in Chinese women. METHODS: This is a subgroup analyses of the F…

BACKGROUND: To investigate the efficacy and safety of estradiol valerate (EV)/dienogest (DNG) for the management of heavy menstrual bleeding (HMB) in Asian and non-Asian women desiring contraception. MATERIALS AND METHODS: In this multicen…

BACKGROUND: To compare potential factors associated with deep infiltrating endometriosis (DIE) versus ovarian endometrioma (OMA) among endometriosis patients in China. METHODS: A subgroup analysis of factors associated with DIE versus OMA …

Endometriosis is an estrogen-dependent disease. Farnesoid X receptor (FXR) activation has been shown to inhibit estrogen signaling in breast cancer and testicular tumors. However, the role of FXR in endometriosis is still poorly understood.…

BACKGROUND: The endometriosis fertility index (EFI) has a predictive value for pregnancy after surgery. In vitro fertilization and embryo transfer (IVF-ET) is a good treatment to infertility. This study aimed to provide external validation …

INTRODUCTION: The present study aimed to investigate clinical, lifestyle, and environmental factors associated with endometrioma (OMA) and/or deep infiltrating endometriosis (DIE) as determined by case-control comparison [women with superfi…

UNLABELLED: Estrogen receptor beta (ERβ, encoded by ESR2 gene) and cytochrome P450 aromatase (encoded by CYP19A1 gene) play critical roles in endometriosis, and the levels of insulin-like growth factor-I (IGF-I) in the peritoneal fluid are …

STUDY OBJECTIVE: To evaluate the safety and efficacy of a new crosslinked hyaluronan (NCH) gel in reducing postoperative adhesions. DESIGN: Randomized controlled trial (Canadian Task Force classification I). SETTINGS: Seven departments of…

CONTEXT: Endometriosis is an estrogen-dependent disease. P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. OBJECTIVE…

BACKGROUND: Cytochrome P450 aromatase (encoded by the CYP19A1/aromatase gene) plays a critical physiologic role in endometriosis. Metformin is known to suppress prostaglandin E2 (PGE2)-induced CYP19A1 messenger RNA (mRNA) expression in huma…

Objective: The aim was to assess the efficacy of post-operative adjuvant treatment with goserelin acetate for reducing the recurrence of pelvic symptoms and total recurrence rates in Chinese patients with moderate to severe endometriosis.

The non-surgical treatment of adenomyosis of the uterus is to relieve dysmenorrhea, to reduce heavy menstrual flow, and to retain or enhance fertility. The main therapeutic methods include medical therapy, uterine artery embolization, and f…

Purpose Exogenic adenomyoma of the cervix is very rare. To date, very few cases have been reported, and the presentation and diagnosis are not clear. The aim of this study was to present 2 cases of exogenic adenomyoma of the cervix and summ…

CONTEXT: Endometriosis is an estrogen-dependent disease affecting reproductive women. Metformin could have a therapeutic effect on endometriosis through regulation of local estrogen production. OBJECTS: The aim of this study was to investi…

BACKGROUND/AIMS: To determine whether the revised American Fertility Society (rAFS) classification and endometriosis fertility index (EFI) predict pregnancy rates (PRs) in patients with surgically confirmed endometriosis attempting natural …

OBJECTIVE: To study pregnancy outcome and recurrence in patients with different type of endometriosis related infertility treated by conservative surgery. METHODS: From January 2005 to December 2010, 79 patients with endometriosis related …

OBJECTIVE: To investigate the expression of integrin β3 and osteopontin (OPN) in the eutopic endometrium of adenomyosis and to characterize possible endometrial defects in adenomyosis. STUDY DESIGN: Twenty-eight adenomyosis patients and 27…

OBJECTIVE: To investigate the expression of steroidogenic factor 1 (SF-1) in eutopic endometrium, ovarian endometriosis (EM) and adenomyosis. METHODS: From Jan. 2008 to Dec. 2010, 30 patients with both ovarian endometriotic cysts and adeno…

OBJECTIVE: To investigate the expression of integrin beta3 and osteopontin (OPN) in eutopic and ectopic endometrium of adenomyosis. METHODS: From January 2007 to July 2008, the endometrium specimens were collected from 43 patients with ade…

OBJECTIVE: To investigate the influence on ovarian reserve function in treatment of ovarian endometriotic cyst by laparoscopic cystectomy with various hemostasis management. METHODS: From September 2007 to August 2008, 61 patients with bil…

OBJECTIVE: To determine whether the expression of leukemia inhibitory factor during the implantation window in endometrial tissue and uterine flushing fluid of patients with adenomyosis differs from that of healthy fertile women. DESIGN: E…

OBJECTIVE: To compare the clinical characteristics of transvaginal hysterectomy (TVH) and total laparoscopic hysterectomy (TLH). METHOD: Clinical data about 301 cases who received TVH and TLH were collected and the hospital stay days, medi…

This in vivo experimental study was designed to investigate the effects of probucol, a hypocholesterolemic agent, on uterine adenomyosis which is frequently induced by pituitary grafting in mice. SHN mice, which are known to develop uterine…