Chen Y

BackgroundCervical intraepithelial neoplasia grade 2 (CIN2) is one of the precursor stages before cervical lesions develop into cervical cancer. The spontaneous development of CIN2 is ambiguous. One part of CIN2 lesions will progress to cer…

BACKGROUND: Uterine fibroids and endometriosis are common benign gynecological diseases affecting the health of women of childbearing age, characterized by high incidence and recurrence rates. Despite the increasing global emphasis on women…

Endometriosis is a prevalent reproductive disorder that affects a significant number of women globally. Cathepsins, which are lysosomal cysteine proteases, contribute to several physiological and pathological processes, including the attach…

OBJECTIVE: To study the MRI characteristics of adenomyosis in secondary infertility patients, and to analyze the factors affecting pregnancy after High-intensity focused ultrasound (HIFU). METHODS: Clinical data of 388 patients with adenom…

The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent implantation failure (RIF). The role of cilia as one …

Proliferative diabetic retinopathy (PDR) is a microvascular complication of diabetes mellitus. Circular RNAs have been implicated in the pathogenesis of PDR. This study aimed to elucidate the specific mechanism by which circFTO contributes …

Background: Acute complicated cholecystitis (ACC) is associated with prolonged hospitalization, increased morbidity, and higher mortality. However, objective imaging-based criteria to guide early clinical decision-making remain limited. Thi…

Ovarian clear cell carcinoma (OCCC) is a subtype of ovarian cancer with a poor prognosis that often shows resistance to chemotherapy. This study retrospectively analyzed 247 patients with OCCC who were admitted to the Cancer Hospital of the…

INTRODUCTION: The robotic surgical system equipped with enhanced visualization, flexible instruments, tremor filtration, and improved ergonomics can greatly address difficulties encountered in conventional laparoendoscopic single-site surge…

ObjectiveTo evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (PDT) for high-grade squamous intraepithelial lesions of the cervix associated with high-risk human papillomavirus (HPV) infection.MethodsIn this study, 120 pat…

BackgroundCervical squamous cell carcinoma (CESC) constitutes a substantial global health burden, especially in resource-limited regions. The identification of reliable biomarkers is critical for developing a clinically applicable nomogram …

BACKGROUND: Endometriosis (EMS), a well-recognized chronic inflammatory disorder, characterized by significant immune dysregulation, in which myeloid-derived suppressor cells (MDSCs) are essential for facilitating immunosuppression and driv…

INTRODUCTION: Pregnancy is a special time during which some benign hormonally-responsive lesions could grow and mimic malignancy on clinical evaluation and imaging. Though decidualization of ovarian endometrioma has been reported, little is…

Pregnancy is a special time during which some benign hormonally-responsive lesions could grow and mimic malignancy on clinical evaluation and imaging. Though decidualization of ovarian endometrioma has been reported, little is known about d…

Diabetic kidney disease (DKD) is recognized as one of the leading causes of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide, representing a rapidly growing global public health concern. Despite significant advance…

BACKGROUND: Adenomyosis is a common gynecological disease and a major contributor to dysmenorrhea that substantially reduces the quality of life of the affected. Dienogest has emerged as a promising drug for treating adenomyosis. A few syst…

Drug repositioning presents a compelling strategy to accelerate therapeutic development by uncovering new indications for existing compounds. However, current computational methods are often limited in their ability to integrate heterogeneo…

OBJECTIVE: To investigate the effects of music therapy combined with mindfulness-based stress reduction on psychological state, pain and sleep in patients with uterine adenomyosis after high-intensity focused ultrasound (HIFU) ablation. ME…

This study investigates changes in regional homogeneity (ReHo) of the brain in patients with adenomyosis accompanied by dysmenorrhea (AMD) before and after uterine artery embolization (UAE) surgery. ReHo is a resting-state functional magnet…

BackgroundUnexplained recurrent pregnancy loss (uRPL), defined as the loss of two or more pregnancies without an identified cause, affects approximately 1-2% of women trying to conceive. Emerging evidence suggests that an imbalance in mater…

As a complex chronic gynecological disorder characterized by multifaceted etiology involving genetics, environment, immunity and inflammation, endometriosis (EM) has long been a significant concern for women of reproductive age worldwide. T…

INTRODUCTION: Endometriosis is a prevalent, estrogen-dependent, inflammatory disease that impairs fertility via hormonal dysregulation, immune dysfunction, oxidative stress/ferroptosis, genetic and epigenetic alterations, and microbiome imb…

This article introduces a novel case report of a patient exhibiting endometriosis within the para-aortic lymph nodes, concomitant with cystic adenomyosis and notably lacking pelvic endometriosis, alongside the sequencing analysis of her les…

BackgroundEndoscopic gallbladder-preserving cholecystolithotomy (EGPC) has become an alternative option for treating cholecystolithiasis. However, developing a new method of EGPC in which the gallbladder wall is not damaged remains a challe…

Biofilms increase bacterial resistance to antibiotics, as conventional antibiotic doses are often ineffective at penetrating the biofilm matrix to eliminate bacteria. Recent research has shown that the Gram-negative predator bacterium Bdell…