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STUDY QUESTION: What is the risk of endometrial cancer after long-term follow-up in women treated with ART between 1983 and 2001 compared with women in the general population and subfertile women who did not undergo ART? SUMMARY ANSWER: Th…
Study questionDo children, adolescents, and young adults born after ART, including IVF, ICSI and frozen-thawed embryo transfer (FET), have an increased risk of cancer compared with children born to subfertile couples not conceived by ART an…
BackgroundLong-term effects of assisted reproductive technology (ART) on ovarian tumor risk are unknown.MethodsThis nationwide cohort study comprises 30 625 women who received ovarian stimulation for ART in 1983-2000 and 9988 subfertile wom…
Study questionDo children conceived by ART have an increased risk of cancer?Summary answerOverall, ART-conceived children do not appear to have an increased risk of cancer.What is known alreadyDespite the increasing use of ART, i.e. IVF or …
STUDY QUESTION: Is ovarian or extra-ovarian endometriosis associated with an increased risk of ovarian cancer and borderline ovarian tumours (BOT)? SUMMARY ANSWER: We found a 3- to 8-fold increased risk of ovarian tumours associated with en…
In fertile women, the endometrium undergoes regular cycles of tissue build-up and regression. It is likely that uterine stem cells are involved in this remarkable turn over. The main goal of our current investigations was to identify slow-c…
BackgroundLong-term effects of ovarian stimulation for IVF on the risk of ovarian malignancies are unknown.MethodsWe identified a nationwide historic cohort of 19,146 women who received IVF treatment in the Netherlands between 1983 and 1995…
Tibolone, a tissue-selective compound with a combination of estrogenic, progestagenic, and androgenic properties, is used as an alternative for estrogen or estrogen plus progesterone hormone therapy for the treatment of symptoms associated …
The authors assessed the accuracy of cause(s) of subfertility as reported by women in a self-administered questionnaire in comparison with medical record information, in a nationwide cohort study of women receiving in vitro fertilization tr…