van Leeuwen FE

Mutagenic processes and clonal selection contribute to the development of therapy-associated secondary neoplasms, a known complication of cancer treatment. The association between tamoxifen therapy and secondary uterine cancers is uncommon …

BackgroundPremenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at high familial risk of ovarian cancer leads to immediate menopause. Although early natural menopause is associated with increased cardiovascular disease risk, evi…

BackgroundThere is concern that assisted reproductive technology (ART) may increase ovarian cancer risk, but previous studies are inconclusive. We compared ovarian cancer risk for women who gave birth after ART vs natural conception.Methods…

Study questionDo children conceived by ART have an increased risk of cancer?Summary answerOverall, ART-conceived children do not appear to have an increased risk of cancer.What is known alreadyDespite the increasing use of ART, i.e. IVF or …

STUDY QUESTION: Is ovarian or extra-ovarian endometriosis associated with an increased risk of ovarian cancer and borderline ovarian tumours (BOT)? SUMMARY ANSWER: We found a 3- to 8-fold increased risk of ovarian tumours associated with en…

BackgroundLong-term effects of ovarian stimulation for IVF on the risk of ovarian malignancies are unknown.MethodsWe identified a nationwide historic cohort of 19,146 women who received IVF treatment in the Netherlands between 1983 and 1995…

The authors assessed the accuracy of cause(s) of subfertility as reported by women in a self-administered questionnaire in comparison with medical record information, in a nationwide cohort study of women receiving in vitro fertilization tr…