Saegusa M

No ORCID on file · 8 papers in corpus · active 2000-2025

Study types

  • article 3
  • other 1

Condition tags

  • endometriosis 4
2025
Prognostic Significance of S100A4 in Ovarian Clear Cell Carcinoma: Its Relation to Tumor Progression and Chemoresistance.
Cancers ·doi:10.3390/cancers17020184

Background/objectivesS100A4, a small calcium-binding protein, promotes metastasis in a variety of human malignancies, but little is known about its involvement in ovarian clear cell carcinoma (OCCC). Herein, we characterized the functional …

article 2019
Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis–associated tumorigenesis
Human pathology ·doi:10.1016/j.humpath.2019.04.001

We focused on specific molecular events during the development of endometriosis-associated ovarian endometrioid carcinoma (OEmCa) and ovarian clear cell carcinoma (OCCCa). Alterations in β-catenin (encoded by CTNNB1) and microsatellite inst…

article 2019
Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions
BMC cancer ·doi:10.1186/s12885-019-5539-y

BACKGROUND: Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tum…

2017
A functional role of LEFTY during progesterone therapy for endometrial carcinoma.
Cell communication and signaling : CCS ·doi:10.1186/s12964-017-0211-0

BackgroundThe left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role in endometrial carci…

2017
Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma.
Oncotarget ·doi:10.18632/oncotarget.18882

To identify proteins involved in ovarian clear cell carcinoma (OCCCa), shotgun proteomics analysis was applied using formalin-fixed and paraffin-embedded samples of ovarian carcinoma. Analysis of 1521 proteins revealed that 52 were differen…

article 2015
Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas
American journal of clinical pathology ·doi:10.1309/ajcpz5t2poofmqvn

OBJECTIVES: We focused on the differences in molecular mechanisms in the early stages of endometriosis-associated ovarian endometrioid carcinoma (OEMCa) and ovarian clear cell carcinoma (OCCCa). METHODS: Alterations in the β-catenin and PIK…

other 2015
Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression
Laboratory investigation; a journal of technical methods and pathology ·doi:10.1038/labinvest.2015.73

Hepatocyte nuclear factor-1β (HNF-1β) is a transcriptional factor that has an important role in endometriosis-ovarian clear cell carcinoma (OCCC) sequence by modulating cell kinetics and glucose metabolism. However, little is known about th…

2000
Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium.
Japanese journal of cancer research : Gann ·doi:10.1111/j.1349-7006.2000.tb00975.x

To clarify changes in estrogen receptor (ER) alpha and ERbeta during endometrial tumorigenesis, 48 endometrial carcinomas (endometrioid type), as well as 40 samples of normal endometrial tissue, were investigated using a combination of reve…