It has been shown in mice that progesterone stimulates both mammary tumourigenesis and uterine adenomyosis in intact animals in the presence of normal levels of prolactin and oestrogen. From the view-point of the high dependence of progeste…
The effects of single pituitary grafting and treatments with progesterone or oestrogen on mammary gland growth and uterine adenomyosis were studied in four strains of female and male mice with different mammary gland growth potentials (SHN/…
As a possible step to estimate the factors controlling the effects of progesterone on mammary tumorigenesis, 3 groups of SHN virgin female mice were treated as follows beginning 2.5-4 months of age: Group A received the subcutaneous implant…
The relative incidence of mammary tumors with uterine adenomyosis was examined in SHN mice subjected to hormonal manipulation between 30 and 90 days of age. The incidence of mammary tumors paralleled that of adenomyosis in controls. A singl…
As a step in the evaluation of the role of growth hormone (GH) in mammary tumorigenesis, the effects of neonatal treatment with monosodium glutamate (MSG) on normal and neoplastic mammary growth, plasma levels of GH and prolactin (PRL) and …
The effects of daily subcutaneous injections of 0.2 mg CB-154 (bromocriptine-mesilate), a potent suppressor of pituitary prolactin secretion, between 4 and 11 weeks of age on the occurrence of spontaneous mammary tumors and adenomyosis, a h…