Gunnar Rannevik

Epostane is a synthetic 17 alpha-alkylated 5 beta-androstane derivative, active following oral administration and devoid of any apparent androgenic, estrogenic or antiestrogenic potency. Circulating concentrations of 13 different plasma pro…

Serum levels of sex hormone binding globulin (SHBG) were measured by radioelectro-immunoassay before and during administration of danazol in daily doses varying between 200 and 800 mg for a period of 1-6 months. The patients consisted of di…

The purpose of the investigation was to study various aspects of danazol treatment in patients with fibrocystic breast disease and pronounced mastodynia. To qualify for inclusion, the patients in this study had to have a mammographically co…

The antigonadotropic action of danazol is still a subject of controversy. Danazol does not cause a consistent and significant suppression of basal gonadotropin concentrations in premenopausal women. In order to investigate the possible effe…

During treatment with danazol the serum concentration of thyroxin-binding globulin (TBG) decreases. This effect is probably a direct effect on TBG production at the cellular level. In order to exclude an indirect effect on TBG production vi…

The hydrolysis of dehydroepiandrosterone sulfate (DHAS) by human liver cells in culture and the hydrolysis of and formation of estradiol-17 beta (E2) from estrone sulfate (E1S) by human breast tumor preparations in vitro were studies in the…

In order to show whether or not danazol exerts direct effects on the cells of the human ovarian follicle, follicular granulosa and thecal cells of follicles in different stages of development are currently being investigated in short-term i…

The synthetic steroid danazol has rapidly become the drug most commonly used in the hormonal treatment of endometriosis and its clinical and endocrine properties in women have been investigated extensively. However, little is known about th…

The purpose of this investigation was to study the influence of danazol on the basal levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), on their response to gonadotropin-releasing hormone (GnRH), as well as the effec…

Cytosol estrogen (ER) and progesterone (PR) receptors were assayed in peritoneal and ovarian endometriotic tissue from 20 patients. In 12 of the cases the intrauterine endometrium was assayed as well. The control material consisted of norma…

The urethral pressure profile was recorded, at rest and under stress, from six women in fertile age, before and at the end of an eight-week treatment during which the probands received daily doses of 600 mg of Danazol. Only moderate decreas…

Analysis of 25 plasma proteins was performed on blood drawn from 7 females before and during treatment with danazol. This steroid was found to induce a pattern of plasma protein changes similar to but not identical with that of other 17 alp…

Assume k (k \\geq 2) populations are given. The associated independent random variables have continuous distribution functions differing only in their unknown location parameter. The statistical selection goal of subset selection is to sele…

A longitudinal study of thyroid function during danazol treatment was performed in 18 women. Serum concentrations of thyroid stimulating hormone (TSH), thyroxine (T4), tri-iodothyronine (T3), free T4-and free T3 index as well as thyroid hor…

The effect of danazol in a dose of 600 mg a day was studied in 20 women with moderate or severe endometriosis. The clinical effect was found to be excellent and repeat laparoscopy after about 6 months treatment revealed a marked regression …