Hiroaki Ishihara

No ORCID on file · 12 papers in corpus · active 2000-2007

Study types

  • article 11
  • other 1

Condition tags

  • endometriosis 12
  • adenomyosis 5
  • dysmenorrhea 1
  • chronic_pelvic_pain 1
article 2007
Association of Killer Cell Immunoglobulin‐like Receptor Genotypes with Susceptibility to Endometriosis
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2007.00533.x

PROBLEM: Endometriosis is an immune-related chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether polymorphisms in killer cell immunoglobulin-like receptors (KIRs) is responsible, in …

article 2007
Maintenance therapy involving a tapering dose of danazol or mid/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.05.052

Pelvic pain associated with endometriosis was treated by the long-term administration of a tapering dose of danazol or mid/low doses of oral contraceptives after the end of therapy involving a GnRH agonist (GnRH-a). Results demonstrated tha…

article 2006
Association of Two Polymorphisms in the Peroxisome Proliferator-Acativated Receptor-γ Gene With Adenomyosis, Endometriosis, and Leiomyomata in Japanese Women
Journal of the Society for Gynecologic Investigation ·doi:10.1016/j.jsgi.2006.03.005

ObjectiveThe peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a nuclear hormone receptor that plays an important role in many diseases. This study investigated whether two polymorphisms (Pro12Ala in exon B and C161T in exon …

article 2006
Synergistic effect of interleukin‐6 promoter (IL6 −634C/G) and intercellular adhesion molecule‐1 (ICAM‐1 469K/E) gene polymorphisms on the risk of endometriosis in Japanese women
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2006.00426.x

PROBLEM: Endometriosis is an immune-related, chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether the interleukin-6 (IL-6) gene promoter region polymorphism (-634C/G) and the interce…

article 2005
Expression of Allograft Inflammatory Factor-1 in Human Eutopic Endometrium and Endometriosis: Possible Association with Progression of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2004-0871

Allograft inflammatory factor-1 (AIF-1) is a cytokine originally identified in rat cardiac allografts with chronic rejection. AIF-1 is expressed in various human immune-related tissues and is thought to play a role in inflammatory responses…

article 2005
Usefulness and limits of CA-125 in diagnosis of endometriosis without associated ovarian endometriomas
Human Reproduction ·doi:10.1093/humrep/deh890

BACKGROUND: The aim of this study was to evaluate the diagnostic significance of CA-125 for endometriosis without ovarian endometriomas. METHODS: Preoperative serum CA-125 levels were measured in 775 consecutive women diagnosed by laparosco…

article 2003
Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas
Fertility and Sterility ·doi:10.1016/s0015-0282(02)04813-6

ObjectiveTo investigate whether GnRH agonists or danazol therapy normalizes estrogen metabolism in the eutopic endometrium of women with endometriosis, adenomyosis, or leiomyomas.DesignProspective clinical study.SettingUniversity hospital.P…

article 2002
Association of HLA class I and class II alleles with susceptibility to endometriosis
Human immunology ·doi:10.1016/s0198-8859(02)00438-x

Although the exact etiology of endometriosis is unclear, several lines of evidence support roles for both cell-mediated and humoral immunity in its pathogenesis. To assess the association between HLA genotypes and endometriosis, we investig…

article 2002
Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women
Human Reproduction ·doi:10.1093/humrep/17.4.897

BACKGROUND: To investigate whether polymorphisms of CYP17 and CYP19 genes are associated with the risk of endometriosis, we analysed the frequency and distribution of a single nucleotide polymorphism at the 5' untranslated region of the CYP…

other 2002
Genetic contribution of the interleukin-10 promoter polymorphism in endometriosis susceptibility
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1034/j.1600-0897.2002.1o029.x

PROBLEM: Interleukin-10 (IL-10) is an important immunomodulatory cytokine. The aim of this study was to investigate whether polymorphisms of the IL-10 gene promoter polymorphisms may be responsible in part for genetic susceptibility to endo…

article 2001
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/s0301-2115(01)00288-3

An immunohistochemical study was made of a case of serous cystadenocarcinoma that had been shown to have arisen from ovarian endometriosis. Aromatase cytochrome P450 (P450arom), an enzyme responsible for estrogen biosynthesis, was localized…

article 2000
Progesterone Induction of 17β-Hydroxysteroid Dehydrogenase Type 2 during the Secretory Phase Occurs in the Endometrium of Estrogen-Dependent Benign Diseases But Not in Normal Endometrium
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.85.9.6829

In the human endometrium, inactivation of 17beta-estradiol to estrone is catalyzed by 17beta-hydroxysteroid dehydrogenase type 2 (17betaHSD2). Previous studies have shown that the 17betaHSD2 activity in the endometrium is elevated during th…