Junjie Sun

OBJECTIVE: To study the therapeutic effect of recombinant adeno-associated virus carrying human endostatin gene therapy on endometriosis in mice model. METHODS: Recombinant adeno-associated virus vector carrying human endostatin gene and en…

Objective:To investigate the effects of endostatin on Ang-2/Tie-2 system in ectopic lesion.Methods:Thirty mice of endometriosis model (EM) were established by peritoneum planted.After 1 week of transplantation,model mice were randomly divid…

Objective:To study the expression of Bcl-2 and proliferating cell nuclear antigen(PCNA) in ectopic endometrum of nude mice.Methods:Sixty nude mice with endometriosis were divided randomly into three groups:the endostatin group (n=20),the gr…

Objective To establish a nude mouse model of human endometriosis.Methods A minilaparotomy was performed to transplant fresh human endometrial pieces into the peritoneum of nude mice.The mice were killed at d7 and d14 after transplantation t…

Objective: To detect the expressions of angiopoietin-2 (Ang-2), Tie-2 and estrogen receptor α (ER-α) in endometriosis and the mechanism thereof. Methods: The expressions of Ang -2, Tie -2 and ER -α were detected by immunohistochemical strep…

OBJECTIVE: To assess interleukin (IL)-1alpha, beta and interferon (IFN) gamma expression in macrophages in eutopic and ectopic endometrium of women with endometriosis. METHODS: In situ hybridization was used to examine the expression of IL-…