Rekker K

No ORCID on file · 8 papers in corpus · active 2013-2018

Study types

  • article 4
  • other 1
  • review 1

Condition tags

  • endometriosis 6
  • endometrioma 1
2018
A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women.
Genes ·doi:10.3390/genes9120574

The endometrium undergoes extensive changes to prepare for embryo implantation and microRNAs (miRNAs) have been described as playing a significant role in the regulation of endometrial receptivity. However, there is no consensus about the m…

article 2018
Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375
International journal of molecular sciences ·doi:10.3390/ijms19123789

microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. However, as both endometrium and endometriotic lesions consist of different cell ty…

review 2017
Challenges in endometriosis miRNA studies — From tissue heterogeneity to disease specific miRNAs
Biochimica et biophysica acta. Molecular basis of disease ·doi:10.1016/j.bbadis.2017.06.018

In order to uncover miRNA changes in endometriosis pathogenesis, both endometriotic lesions and endometrial biopsies, as well as stromal and epithelial cells isolated from these tissues have been investigated and a large number of dysregula…

article 2017
High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium
Reproduction (Cambridge, England) ·doi:10.1530/rep-17-0092

Abstract The aetiology of endometriosis is still unclear and to find mechanisms behind the disease development, it is important to study each cell type from endometrium and ectopic lesions independently. The objective of this study was to u…

article 2016
The influence of menstrual cycle and endometriosis on endometrial methylome
Clinical epigenetics ·doi:10.1186/s13148-015-0168-z

BACKGROUND: Alterations in endometrial DNA methylation profile have been proposed as one potential mechanism initiating the development of endometriosis. However, the normal endometrial methylome is influenced by the cyclic hormonal changes…

other 2015
Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.06.029

OBJECTIVE: To determine whether circulating micro-RNA (miR) 200a, miR-200b, and miR-141 have altered levels in patients with endometriosis compared with control individuals. DESIGN: Experimental laboratory study. SETTING: University. PAT…

article 2014
High-Throughput Sequencing Approach Uncovers the miRNome of Peritoneal Endometriotic Lesions and Adjacent Healthy Tissues
PloS one ·doi:10.1371/journal.pone.0112630

Accumulating data have shown the involvement of microRNAs (miRNAs) in endometriosis pathogenesis. In this study, we used a novel approach to determine the endometriotic lesion-specific miRNAs by high-throughput small RNA sequencing of paire…

2013
Circulating microRNA Profile throughout the menstrual cycle.
PloS one ·doi:10.1371/journal.pone.0081166

Normal physiological variables, such as age and gender, contribute to alterations in circulating microRNA (miRNA) expression levels. The changes in the female body during the menstrual cycle can also be reflected in plasma miRNA expression …