Tang L

The immune system is a pivotal regulator of reproductive physiology, maintaining tissue homeostasis essential for successful pregnancy while contributing to infertility and reproductive disorders when dysregulated. Natural products represen…

BACKGROUND: Endometriosis is a hormone-related gynecological disease and characterized by the invasion of endometrial cells outside the uterine cavity. OBJECTIVE: This study aimed to investigate the impact of goserelin acetate implants on …

This narrative review synthesizes the latest advances in nano-diagnostic and therapeutic reagents for acute pancreatitis (AP), based on peer-reviewed experimental and preclinical studies published in recent years. AP endangers life through …

Endometriosis (EMs) is a disease characterized by the presence of endometrial tissue outside the uterus, which often causes pain, abnormal bleeding, and infertility. Sirtuin 1 (SIRT1)-mediated deacetylation is implicated in the progression …

Polycystic ovary syndrome (PCOS) exacerbated by obesity represents a complex intersection of endocrine and immune dysregulation, significantly impairing reproductive and metabolic health. This characterizes the immune-inflammatory landscape…

BACKGROUND: Insulin resistance (IR) is a key metabolic disturbance that adversely affects assisted reproductive technology (ART) outcomes. In women with polycystic ovary syndrome (PCOS), IR has been well documented to impair oocyte quality,…

BackgroundFallopian tube carcinoma is one of the most malignant gynecological tumors, with its exact etiology remaining largely unclear. Genetic factors contribute to ~20% of ovarian, fallopian tube, and peritoneal cancers, and gene polymor…

RESEARCH QUESTION: Can bioinformatics-driven identification of hub genes in granulosa cells be used to predict oocyte developmental potential in patients with endometriosis (EMS)-related infertility? DESIGN: This was an exploratory cohort …

Epithelial-myoepithelial carcinoma (EMC) of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Breast epithelial myoepithelial carcinoma lacks therapeutic strategies due to its rari…

PURPOSE: To investigate the impact of changing to the PPOS protocol in the population with a premature progesterone increase (≥ 0.9 ng/mL) from the antagonist protocol on the clinical outcomes. METHODS: The study was a retrospective cohort,…

BACKGROUND: Substantial impacts on the female reproductive system have been definitively linked to heightened levels of serum uric acid. However, evidence directly linking increased serum uric acid levels to endometriosis in women remains s…

OBJECTIVE: This study aimed to identify and validate potential immune-related genes in endometriosis (Ems) through comprehensive bioinformatics analysis and immunohistochemistry (IHC) verification. DESIGN: Using data from the GEO database,…

BackgroundOvarian cancer (OV) is the deadliest gynecologic malignancy owing to its late diagnosis and high metastatic propensity. Current biomarkers lack sufficient sensitivity and specificity for the detection of early-stage cancer. To add…

Background and objectivesOligomenorrhea and hypomenorrhea were common conditions in outpatient visit which affected child-bearing aged women, and the conventional progesterone treatment has been related to several side effect and contradict…

Long non-coding RNAs (lncRNAs) play critical roles in development and pathogenesis of various diseases. Notably, lncRNA-metastasis-associated lung adenocarcinoma transcript 1(MALAT1) is among the most essential lncRNAs affecting various pro…

BackgroundHuman Papillomavirus (HPV) infection is a ubiquitous sexually transmitted infection globally, frequently associated with sexual behaviors characterized by increased frequency and multiple partnerships. The relationship between var…

Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cause, as not all affected women develop EMs. Emerging evidence suggests a significant association between the vaginal mi…

ObjectiveMany epithelial ovarian cancer (EOC) risk factors relate to sex hormones. The association between these factors and the expression of androgen receptor (AR), estrogen receptor-α (ER), and progesterone receptor (PR) in tumors is unk…

BackgroundGynecological diseases significantly impact the reproductive health in women of childbearing age (WCBA). However, there is currently a lack of analysis on the specific burden and forecast of common gynecological diseases for this …

PurposeTo explore the value of high-intensity focused ultrasound (HIFU) ablation and laparoscopic myomectomy (LM) in the treatment of uterine fibroids.MethodsOne hundred and twenty patients with uterine fibroids admitted to our hospital fro…

ObjectiveThis study aims to investigate alterations in immune cell counts within preovulatory follicles of patients with poor ovarian response (POR) during assisted reproductive technology (ART), classified according to the POSEIDON criteri…

Jia Bian, Hongfeng Li, Yaping Shang, Fang Zhang, Lifei Tang Department of Gynecology and Obstetrics, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, People’s Republic of ChinaCorrespondence: Jia Bian, Department of …

BACKGROUND: Gynecological disorders are a wide range of health problems affecting the female reproductive system, which poses substantial health challenges worldwide. Increasing number of observational studies have associated mood instabili…

PurposeTo develop a deep learning (DL) model for differentiating between benign and malignant ovarian tumors of Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS US) Category 4 lesions, and validate its diagnostic performance.Met…

PurposeStruma ovarii is a highly specialized teratoma consisting primarily of mature thyroid tissue. However, malignant struma ovarii coexisting with thyroid carcinoma, not to mention autoimmune disease, is uncommon. Malignant struma ovarii…