Shima T

No ORCID on file · 9 papers in corpus · active 2011-2025

Study types

  • article 3
  • review 2

Condition tags

  • endometriosis 5
  • infertility 1
  • endometrioma 1
2025
Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging
·doi:10.20944/preprints202507.0406.v1

Organ functions generally decline with age, but the ovary is a prototypical organ that undergoes functional loss over time. Autophagy plays a crucial role in maintaining organ homeostasis, and age-related upregulation of the autophagy inhib…

review 2025
Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian Aging
Antioxidants (Basel, Switzerland) ·doi:10.3390/antiox14080919

Organ functions generally decline with age, but the ovary is a prototypical organ that undergoes functional loss over time. Autophagy plays a crucial role in maintaining organ homeostasis, and age-related upregulation of the autophagy inhib…

2025
Rubicon, a Key Molecule for Oxidative Stress-Mediated DNA Damage, in Ovarian Granulosa Cells.
Antioxidants (Basel, Switzerland) ·doi:10.3390/antiox14040470

Aging drives excessive ovarian oxidative stress (OS), impairing fertility and affecting granulosa cells (GCs), which are involved in folliculogenesis. This study aims to clarify the relationship between OS and autophagy in GCs and to identi…

2023
The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field.
Biology ·doi:10.3390/biology12030373

Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decade…

article 2019
Sphingosine I Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719119828112

ObjectsThere is growing evidence that sphingosine 1-phosphate (S1P) is involved in inflammatory diseases. As endometriosis is known as an inflammatory disease, we investigated the role of S1P system in the development of endometriosis.Metho…

article 2018
Three cases of clear‐cell adenocarcinoma arising from endometrioma during hormonal treatments
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13702

Endometrioma is known to be an occurrence site of ovarian cancer, but there is no evidence on how to reduce the risk of canceration. Here, we report three cases of ovarian cancer arising from endometrioma during hormone therapies of GnRH an…

article 2016
Alpha‐7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12592

OBJECTIVE: We investigated α-7 nAchR expression in human peritoneal macrophages and examined whether activation of nAchR might be a new therapy for endometriosis. MATERIALS AND METHODS: Human peritoneal fluid mononuclear cells (PFMC) were s…

2015
Isolated torsion of the fallopian tube in a menopausal woman and a pre-pubertal girl: two case reports.
Journal of medical case reports ·doi:10.1186/s13256-015-0745-y

IntroductionIsolated torsion of the fallopian tube without an ovarian abnormality is an uncommon event, with an incidence of approximately 1 in 1,500,000 females. Isolated torsion of the fallopian tube occurs mostly in reproductive-aged wom…

review 2011
Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology
Expert review of clinical immunology ·doi:10.1586/eci.11.49

The identification of a novel helper T (Th)-cell subset, the IL-17-producing Th (Th17) cells, has provided new insight into our understanding of the molecular mechanisms of reproduction. IL-17 has an important role in induction of the prote…