Benjamin G Bitler

Abstract Ovarian clear cell carcinoma (OCCC) is an aggressive, endometrial-derived subtype of ovarian cancer (OvCa) which affects young women. Late stage OCCC is resistant to chemotherapy and has the worst outcome compared to other OvCa sub…

Background/Objectives: Ovarian cancer (OC) is frequently diagnosed at an advanced stage due to the nonspecific nature of its symptoms. While population-wide screening has failed to reduce mortality, timely diagnosis in symptomatic women rem…

OBJECTIVE: Symptoms occur in up to 75% of patients with early-stage ovarian cancer; as such, using a symptom inventory (SI) to stratify which patients should receive screening for ovarian cancer is an attractive approach to mitigate false-p…

Ovarian cancer is the fifth leading cause of cancer-related deaths among women. Most patients are diagnosed at late stage (III/IV), resulting in a 5-year survival rate below 30%. This is driven by the presentation of vague abdominal symptom…

BioID setup and proof-of-concept

Wnt ligand WNT4 is critical in female reproductive tissue development, with WNT4 dysregulation linked to related pathologies including breast cancer (invasive lobular carcinoma, ILC) and gynecologic cancers. WNT4 signaling in these contexts…

Gynecologic malignancies, including ovarian cancer, endometrial cancer, and cervical cancer, affect hundreds of thousands of women worldwide every year. Wnt signaling, specifically Wnt/β-catenin signaling, has been found to play an essentia…