Madeleine T. Shackleford

article 2025

Abstract B037: WNT4-mediated metabolomic reprograming favors lipid utilization in ovarian clear cell carcinoma

·doi:10.1158/1538-7445.ovarian25-b037

Abstract Ovarian clear cell carcinoma (OCCC) is an aggressive, endometrial-derived subtype of ovarian cancer (OvCa) which affects young women. Late stage OCCC is resistant to chemotherapy and has the worst outcome compared to other OvCa sub…

preprint 2024

Supplemental Figure 1 from WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers

·doi:10.1158/2767-9764.25012804

BioID setup and proof-of-concept

2024

WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers.

Cancer research communications ·doi:10.1158/2767-9764.crc-23-0275

Wnt ligand WNT4 is critical in female reproductive tissue development, with WNT4 dysregulation linked to related pathologies including breast cancer (invasive lobular carcinoma, ILC) and gynecologic cancers. WNT4 signaling in these contexts…

2020

Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4.

Cancers ·doi:10.3390/cancers12102931

Invasive lobular carcinoma of the breast (ILC) is strongly estrogen-driven and represents a unique context for estrogen receptor (ER) signaling. In ILC, ER controls the expression of the Wnt ligand WNT4, which is critical for endocrine resp…