Gao Y

Although a putative role for transforming growth factor-β (TGFB) signalling in the pathogenesis of human endometrial cancer has long been proposed, the precise function of TGFB signalling in the development and progression of endometrial ca…

Cancer metastasis is a malignant process by which tumor cells migrate from their primary site of origin to other organs. It is the main cause of poor prognosis in cancer patients. Angiogenesis is the process of generating new blood capillar…

OBJECTIVE: To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and trans- forming growth factor (TGF) -β1gray level in SD rats. MATERIALS AND METHODS: EMS was surgically induced i…

Cancer induced bone pain is a very complicated clinical pain states that has proven difficult to be treated effectively due to poorly understand of underlying mechanism, but bone cancer pain (BCP) seems to be enhanced by a state of spinal s…

Background. Dysmenorrhea is a common problem for which acupuncture provides effective analgesia. Although acupoint selection affects the effectiveness of acupuncture, the basic rules of acupoint selection are little understood. This study a…

BACKGROUND: It is well-known that the treatment and monitoring methods are limited for advanced stage of endometrial carcinoma. Biological molecules with expression changes during tumor progression become potential therapeutic targets for a…

In this systematic review and meta-analysis, the effect of ovarian endometrioma on ovarian responsiveness to stimulation and on assisted reproduction outcomes was evaluated. Nine published studies (1039 cases) were included. The number of o…

OBJECTIVE: To evaluate the application of transvaginal hydrolaparoscopy for exploration of the pelvic cavity exploration in infertile women. STUDY DESIGN: A total of 510 infertile women were included in this study from May 1st, 2009 to Apr…

OBJECTIVE: To investigate the role of DNA methylation in the regulation of matrix metalloproteinase 9 (MMP-9) gene expression in endometriosis. METHODS: MMP-9 gene methylation status in eutopic and ectopic endometria were analyzed by methy…

OBJECTIVE: To establish a gas chromatography/mass spectrometry (GC/MS)-based metabolomics method to compare the metabolites in the follicular fluid (FF) from patients with in vitro fertilization (IVF) and repeated IVF failure (RIF). METHOD…

The smooth muscle layer of the uterus (ie, myometrium) is critical for a successful pregnancy and labor. We have shown that the conditional deletion of TGFβ type 1 receptor (TGFBR1) in the female reproductive tract leads to remarkable smoot…

PURPOSE: Over expression of tissue factor (TF) occurs in more than 50 % of colorectal cancer (CRC). Therefore, TF represents an attractive target antigen for immunotherapy in CRC. METHODS: Here, we assessed the safety and efficacy of a rec…

BACKGROUND: Diagnosis of ovarian cancer is often delayed because of subtle symptoms and a lack of a specific, sensitive test useful for the general population. The majority of cases are diagnosed at late stages, after the tumor has metastas…

OBJECTIVE: To evaluate the role of the novel tumor marker human epididymal secretory protein E4 (HE4) in discriminating ovarian cancer from benign pelvic disease in patients with a pelvic mass. METHODS: Serum samples from 131 patients with…

BACKGROUND: The lymphatic system is a major route for cancer cell dissemination and also a potential target for antitumor therapy. To investigate whether increased lymphatic vessel density (LVD) is a prognostic factor for nodal metastasis a…

OBJECTIVE: To investigate the correlation of endometriotic focus and peritoneal fluid as well as its effect on reproduction. METHODS: Forty-three women with surgical treatment or laproscope with infertility are divided into endometriosis g…

OBJECTIVE: To observe the therapeutic effect of Tripterygium wilfordii Hook. f. on patients with uterine leiomyoma. METHODS: Baseline ultrasound examinations of myomas and uterine were obtained and repeated three months, six months after t…

OBJECTIVE: To investigate the clinical significance of monocyte chemotactic protein-1 (MCP-1) produced by endometriotic tissues. METHODS: Expressions of MCP-1 mRNA and MCP-1 protein were determined by dot blot analysis, immunohistochemical…

To investigate the clinical significance of monocyte chemotactic protein-1 (MCP-1) produced by endometriotic tissues, the endometriotic tissues were taken from 15 patients with endometriosis. MCP-1 mRNA and MCP-1 protein were determined by …

OBJECTIVE: To clarify whether apoptosis is involved in endometriosis and the effects of estradiol, progesterone and mifepristone on the expression of epidermal growth factor receptor(EGFR) in cultured human endometriotic cells. METHODS: Ap…