[Clinical study on effect of Tripterygium wilfordii Hook. f. on uterin leiomyoma].

OBJECTIVE: To observe the therapeutic effect of Tripterygium wilfordii Hook. f. on patients with uterine leiomyoma. METHODS: Baseline ultrasound examinations of myomas and uterine were obtained and repeated three months, six months after treatment. Blood samples were collected in the mid-follicular or mid-luteal phase of the menstrual cycle before initiation of Tripterygium wilfordii Hook. f. therapy and after treatment 3-4 months and 5-6 months, for determination of estradiol, progesteron, testosterone, follicle-stimulating hormone, luteinizing hormone and prolactin by radioimmunoassay. RESULTS: Significant decrease in leiomyoma volume was detected in 39 of 65 (60.0%) patients after 3-4 months of Tripterygium wilfordii Hook. f. treatment and 28 of 40 (70.0%) patients after 5-6 months of treatment. The decrease in leiomyoma volume with Tripterygium wilfordii Hook. f. treatment was time-dependent while 27.84% in 3-4 months, 51.6% in 5-6 months. 25 of 65 patients were amenorrheic during the course of treatment. Compared with pretreatment values, Tripterygium wilfordii Hook. f. treatment induced an increase in mean luteinizing hormone, fdlicle-stimulating hormone levels and a decrease in mean estradiol, progesterone levels. CONCLUSIONS: Tripterygium wilfordii Hook. f. may be an effective therapeutic agent for leiomyomas with fewer side effects. Tripterygium wilfordii Hook. f. treatment showed a reversibly inhibitory effect on the ovary. It may be one of the mechanisms of Tripterygium wilfordii Hook. f. in decreasing leiomyoma volume.