Liu N

ObjectiveTo compare the postoperative analgesic efficacy of oliceridine versus sufentanil in patients undergoing total laparoscopy hysterectomy.MethodsIn this double-blind, randomized controlled trial, 80 patients scheduled for elective tot…

INTRODUCTION: Adenomyosis, which affects > 20% of reproductive-age women, is a major cause of infertility. Defective decidualization of endometrial stromal cells (ESCs) is a key pathogenic feature of adenomyosis; however, the underlying red…

BACKGROUND: Impaired decidualization is a major cause of infertility in patients with adenomyosis (AM). However, the effect of transcription factor 21 (TCF21) on AM and the underlying mechanism of associated-impaired decidualization remain …

PurposeThis study aims to assess the impact of ultrasound parameters on endometrial receptivity in patients undergoing IVF-ET and to establish a predictive model for ongoing pregnancy outcomes.MethodsThe prospective cohort study included 86…

BackgroundThe weekend effect is a controversial epidemiological phenomenon that has rarely been reported in the assisted reproductive technology (ART) setting, particularly among first-cycle fresh embryo transfer (ET) populations undergoing…

Spatial transcriptomics enables in situ molecular profiling, allowing to measure the cellular transcriptional output within the tissue. As the tissue architecture is conserved, spatial domains with specific transcriptional patterns can be i…

We aimed to examine abnormal oxidative lipid levels and their related mechanisms in EM-associated infertility. Through liquid chromatography tandem mass spectrometry analysis, decreased levels of epoxyeicosatrienoic acids (EETs), which have…

PurposeTo compare pregnancy outcomes of four endometrial preparation methods prior to frozen embryo transfer (FET).MethodsA total of 3,030 programmed cycles were analyzed: 302 with natural cycle (NC), 131 with ovulation induction (OI), 1,07…

PurposeThis study aims to establish a single-time point RNA-sequencing-based endometrial receptivity test (rsERT) to provide hourly precision of endometrial WOI for patients with recurrent implantation failure (RIF).MethodsA two-phase study…

Endometrial cancer stands as a prevalent malignant tumor of the female genital tract, while showing growing incidence statistics. Circular RNAs (circRNAs) demonstrate translational value as biomarkers and therapeutic targets in endometrial …

To evaluate whether the Spring Festival has an effect on the outcomes of patients undergoing their first embryo transfer (ET) via in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). We conducted a retrospective cohort study …

PURPOSE: To evaluate whether the inflammatory proteomics of uterine fluid is feasible in defining the endometrial receptivity phase. METHODS: Inflammatory proteomics of uterine fluid was measured using the OLINK Target-96 Inflammation panel…

Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they ofte…

Endometriosis, a gynecological disorder marked by pelvic pain and infertility, has its pathogenesis and pathophysiology significantly influenced by epigenetics, as these factors have been well characterized. However, the role of RNA-mediate…

Gynecologic cancers (GCs), including cervical cancer (CC), ovarian cancer (OC), endometrial cancer (EC), as well as vulvar and vaginal cancers, represent major health threats to women, with increasing incidence rates observed globally. Conv…

BackgroundAge-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important roles in ovarian tissue homeostasis and immune surveillance. However, the impact of aging on ovarian macroph…

BackgroundTo evaluate the risk factors associated with WOI (window of implantation) displacement based on ERT (endometrial receptivity test), and to confirm the association of ectopic pregnancy with WOI displacement.MethodsThis is a retrosp…

BackgroundCognitive biases in clinical decision-making significantly contribute to errors in diagnosis and suboptimal patient outcomes. Addressing these biases presents a formidable challenge in the medical field.ObjectiveThis study aimed t…

PurposeTo investigate whether personalized embryo transfer (pET) predicted by a modified RNA-sequencing-based endometrial receptivity test (rsERT) model can improve intrauterine pregnancy rate (IPR) in patients with a receptive window of im…

Vaginal atresia is a rare obstructive disease of the reproductive tract. It is characterized by the absence or underdevelopment of the vaginal canal and results in various clinical manifestations. Hysterectomy can physically and mentally bu…

BackgroundThe study investigated whether specific ultrasonographically observed endometrial features (including endometrium type and thickness) were linked to ectopic pregnancy after stimulated cycles with fresh embryo transfer.MethodOf 624…

BackgroundEmbryo implantation in a receptive endometrium is crucial for successful pregnancy. Endometrial receptivity (ER) prediction tools based on endometrial transcriptome biomarkers by endometrial biopsy have been used to guide successf…

BackgroundNeuroimaging studies have identified altered brain structures and functions in women with primary dysmenorrhea (PDM). However, previous studies focused on either structural or functional changes in specific brain regions rather th…

ObjectiveTo determine whether a reduced dose of follicle-stimulating hormone (FSH) before human chorionic gonadotropin (hCG) trigger during ovarian stimulation can affect in vitro fertilization (IVF) outcomes.MethodsThis study included 347 …

Endometriosis is a common gynecological disorder that causes female infertility. Our recent research found that excessive oxidative stress in ovaries of endometriosis patients induced senescence of cumulus granulosa cells. Here, we analyzed…