Gary D. Hodgen — Endo Lab

article 1998

Chronic Antiprogestin Therapy Produces a Stable Atrophic Endometrium With Decreased Fibroblast Growth Factor: A 1-Year Primate Study on Contraception and Amenorrhea

·doi:10.1016/s0015-0282(98)00029-6

ObjectiveTo describe the efficacy of mifepristone in the prevention of menstrual bleeding and ovulation, with similar observations in comparison groups.DesignProspective experimental study. Thirty-two cynomolgus monkeys were divided equally…

article 1996

Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study.

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.81.5.8626860

The fact that RU 486 curtailed estrogen-induced endometrial proliferation in primates and relieved pelvic pain in women with endometriosis is the reason for continuing research on antiprogestins. Thirty-two adult female cynomolgus monkeys d…

article 1996

Antiproliferative effects of low-dose micronized progesterone

·doi:10.1016/s0015-0282(16)58093-5

ObjectiveTo study the pharmacodynamic effects of oral micronized P on endometrial maturation.DesignThis was a controlled, open, parallel group, pilot study.SettingThe experiment was performed in an outpatient academic clinical research unit…

article 1996

Inhibition of ovulation by progestin analogs (agonists vs antagonists): Preliminary evidence for different sites and mechanisms of actions

·doi:10.1016/0010-7824(95)00255-3

Continuous administration of the antiprogesterone RU486 inhibits ovulation in women and in monkeys; in this regard RU486 may act as a progestin agonist rather than as an antagonist. We compared the site(s) and mechanism(s) of RU486-induced …

editorial 1991

Antiprogestins: the political chemistry of RU486

Fertility and Sterility ·doi:10.1016/s0015-0282(16)54528-2

article 1991

Gonadotropin-releasing hormone agonist-induced ovarian hyperstimulation: low-dose side effects in women and monkeys

·doi:10.1016/s0015-0282(16)54354-4

ObjectiveTo determine whether low (subtherapeutic) doses of gonadotropin-releasing hormone agonists (GnRH-a) can cause ovarian hyperstimulation.DesignThe study is in two parts: a preliminary clinical trial of women and a follow-up study in …

book-chapter 1985

Reversible pharmacologic castration of the female: implications for endometriosis, contraception and ovulation induction

·doi:10.1515/9783110861488-012

other 1984

Etiology of infertility in monkeys with endometriosis: luteinized unruptured follicles, luteal phase defects, pelvic adhesions, and spontaneous abortions

Fertility and Sterility ·doi:10.1016/s0015-0282(16)47552-7

To elucidate the etiology of infertility due to endometriosis, we autografted endometrial or adipose tissue to the pelvic peritoneum of 21 cynomolgus monkeys. These primates were divided into five groups: control animals with adipose tissue…

article 1984

Etiology of infertility in monkeys with endometriosis: Measurement of peritoneal fluid prostaglandins

American Journal of Obstetrics and Gynecology ·doi:10.1016/s0002-9378(84)80136-2

To study the relationship between peritoneal fluid prostaglandins and infertility associated with endometriosis, we autografted endometrial or adipose tissue to the pelvic peritoneum in 21 monkeys. Peritoneal washings were collected prior t…

article 1983

Gonadotropin-Releasing Hormone Agonist Suppresses Ovulation, Menses, and Endometriosis in Monkeys: An Individualized, Intermittent Regimen*

The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem-56-4-844

This study was designed to test the efficacy of a long-acting GnRH agonist (alpha) for inhibition of ovulation and menses in monkeys as well as suppression of mild to moderate endometriosis through an individualized, intermittent regimen. E…

article 1980

Endometriosis: Role of Ovarian Steroids in Initiation, Maintenance, and Suppression

Fertility and Sterility ·doi:10.1016/s0015-0282(16)44780-1

Although endometriosis is commonly associated with infertility, the hormonal requirements for its spontaneous initiation and maintenance remain unknown. Since endometriosis occurs in the monkey, these primates are useful for examining the h…