Etiology of infertility in monkeys with endometriosis: luteinized unruptured follicles, luteal phase defects, pelvic adhesions, and spontaneous abortions

Robert S. Schenken, R S Schenken, Ricardo H. Asch, R H Asch, Robert F. Williams, R F Williams, Gary D. Hodgen, G D Hodgen
Fertility and Sterility · 1984 · doi:10.1016/s0015-0282(16)47552-7 · PMID:6420199
other OA: closed public-domain-us ⤵ 3 in-corpus citations
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Endometriosis in monkeys impaired fertility by causing luteinized unruptured follicles, pelvic adhesions, and spontaneous abortions, with moderate to severe disease showing the lowest pregnancy rates.

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Abstract

To elucidate the etiology of infertility due to endometriosis, we autografted endometrial or adipose tissue to the pelvic peritoneum of 21 cynomolgus monkeys. These primates were divided into five groups: control animals with adipose tissue autografts (n = 5), animals with microscopic endometriosis (n = 5), animals with mild endometriosis (n = 5), animals with moderate endometriosis (n = 4), and animals with severe endometriosis (n = 2). During three subsequent menstrual cycles, each animal underwent (1) serial assay of peripheral serum gonadotropins and steroids; (2) mating timed according to daily serum 17 beta-estradiol; and (3) laparotomy to document an ovulatory stigma. The chemical and term pregnancy rates were lower among monkeys with moderate or severe endometriosis, as compared with control animals. The impaired fertility in monkeys with endometriosis appeared to be mediated primarily by failure of follicular rupture and/or pelvic adhesions.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Abortion, Spontaneous Endometriosis Infertility, Female Luteal Phase Menstruation Ovarian Follicle Pelvic Inflammatory Disease Abortion, Spontaneous Animals Endometriosis Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Infertility, Female Luteinizing Hormone Luteinizing Hormone Macaca fascicularis Ovarian Follicle

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (3)

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