R. Charles Coombes

ORCID: 0000-0002-4811-1100 · 10 papers in corpus · active 1981-1994

Study types

  • article 10
article 1994
Gestrinone in mastalgia: A randomized double blind placebo controlled trial
·doi:10.1016/0960-9776(94)90005-1

78 patients with mastalgia associated with benign breast disease were randomized to treatment with the synthetic steroid gestrinone (2.5 mg twice weekly) or placebo for 3 months. Breast pain scores, which were similar in the two groups prio…

article 1990
Combination of tamoxifen, aminoglutethimide, danazol and medroxyprogesterone acetate in advanced breast cancer
·doi:10.1016/0277-5379(90)90162-m
article 1986
Response of nitrosomethylurea-induced rat mammary tumor to endocrine therapy and comparison with clinical response.

We have compared the response of the N-methyl-N-nitrosourea-induced rat mammary tumor to various endocrine agents with response in patients with breast cancer. To do this, we have induced tumors in 228 animals (65% of intact rats developed …

article 1984
TREATMENT OF DISSEMINATED BREAST CANCER WITH TAMOXIFEN, AMINOGLUTETHIMIDE, HYDROCORTISONE, AND DANAZOL, USED IN COMBINATION OR SEQUENTIALLY
·doi:10.1016/s0140-6736(84)91872-5
article 1983
246 Treatment of disseminated breast cancer with multiple hormone therapy using tamoxifen, danazol, aminoglutethimide and hydrocortisone
·doi:10.1016/0022-4731(83)91746-6
article 1983
Danazol treatment for advanced breast cancer
·doi:10.1007/bf00255761
article 1983
Prognostic significance of serum prolactin levels in advanced breast cancer
·doi:10.1038/bjc.1983.129
article 1982
Clinical trial of multiple endocrine therapy for metastatic and locally advanced breast cancer with tamoxifen-aminoglutethimide-danazol compared to tamoxifen used alone.

Multiple-endocrine therapy with combinations of various types of treatment has not been evaluated properly in spite of the success of individual types of hormone treatment. This paper reports the early results of a randomized controlled cli…

article 1982
Tamoxifen, aminoglutethimide and danazol: effect of therapy on hormones in post-menopausal patients with breast cancer
·doi:10.1038/bjc.1982.161
article 1981
Danazol treatment of advanced breast cancer.

Danazol, an effective agent in the treatment of benign breast disease, has been administrated to 41 patients with advanced breast cancer. These patients were treated with danazol for periods ranging from 1 to 40 weeks and responses were see…