Prognostic significance of serum prolactin levels in advanced breast cancer

Mitch Dowsett, M Dowsett, Gail McGarrick, G E McGarrick, Adrian L. Harris, A L Harris, R C Coombes, R. Charles Coombes, I. E. Smith, S L Jeffcoate
British journal of cancer · 1983 · vol. 47(6) , pp. 763–769 · doi:10.1038/bjc.1983.129 · PMID:6860546 · PMC2011370 · W2037045892
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In 135 postmenopausal patients with advanced breast cancer, serum prolactin levels greater than or equal to 500 mIUl-1 were associated with poor response to endocrine therapy and significantly shorter survival.

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Abstract

Serum prolactin concentrations were measured in 135 postmenopausal patients with advanced breast cancer prior to their treatment with one of 3 endocrine therapies: aminoglutethimide (AG), tamoxifen (T) + AG, or T + AG + danazol. The mean level of prolactin was higher, and there were more individuals with levels of prolactin greater than or equal to 500 mIUl-1, in the group of patients who did not respond to treatment. Of the patients whose disease progressed, those with prolactin levels greater than or equal to 500 mIUl-1 had a significantly shorter survival. It appears that high prolactin levels indicate a poor prognosis to endocrine therapy and the probability of a shorter than average survival time.

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MeSH descriptors

Breast Neoplasms Prolactin Aminoglutethimide Aminoglutethimide Breast Neoplasms Breast Neoplasms Breast Neoplasms Danazol Danazol Drug Therapy, Combination Female Humans Menopause Prognosis Prolactin Tamoxifen Tamoxifen

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